Bcl2 negatively regulates Protective Immune Responses During Mycobacterial Infection
Background and goals: Osteosarcopenia (OS), characterised by the coexistence of osteoporosis (OP) and sarcopenia (SP), is related to excessive morbidity and mortality within the aged. Nonetheless, its pathogenesis and therapy stay unclear. The purpose of this research was to analyze the impact and mechanism of Zhuanggu Zhitong Capsule (ZGZT) in OS rats.
Strategies: All of the associated targets of OS, corresponding targets for bioactive elements of ZGZT, intersection targets of ZGZT in opposition to OS, and signaling pathways had been predicted and analyzed by community pharmacology. Subsequent, a rat OS mannequin was established by ovariectomy (OVX) and injection of dexamethasone (DXM). Rats had been then randomly divided right into a Management group, a Sham operation group, an OS mannequin group, an OS+ZGZT group, and an OS+E2 group. The drug was given for 12 weeks. Throughout therapy, physique weight, forelimb grip and physique composition had been measured. As well as, bone mineral density (BMD) and micro CT had been used to evaluate the left femur. After therapy, the left femur, left gastrocnemius, and left soleus, in addition to uterus, liver, and kidney, had been separated and analyzed utilizing Histomorphology, Western blot, and quantitative real-time PCR (qRT-PCR).
Outcomes: ZGZT may successfully enhance the phenotypes of OS by growing forelimb grip power, share lean mass of the entire physique (SMI) or appendicular lean (RSMI), BMD, ranges of bone formation markers, enhancing the microstructure of femur, and lowering apoptotic price in femur and gastrocnemius in OS rats by up-regulating PI3K/Akt/Bcl2 sign pathway.
Conclusions: ZGZT could also be a brand new therapy choice for the prevention and therapy of OS.
Key phrases: Animal mannequin; Community pharmacology; Osteosarcopenia; PI3K/Akt/Bcl2; Zhuanggu Zhitong Capsule.
Bcl2 negatively regulates Protecting Immune Responses Throughout Mycobacterial An infection
We beforehand reported that M. tb by itself in addition to along with HIV inhibits macrophage apoptosis by upregulating the expression of Bcl2 and Inhibitor of Apoptosis (IAP). As well as, current studies from our lab confirmed that stimulation of both macrophages or BMDCs leads to the numerous upregulation of Bcl2. On this report, we delineate the function of Bcl2 in mediating protection responses from dendritic cells (BMDCs) throughout mycobacterial an infection.
Inhibiting Bcl2 led to a big lower in intracellular bacterial burden in BMDCs. To additional characterize the function of Bcl2 in modulating protection responses, we inhibited Bcl2 in BMDCs in addition to human PBMCs to watch their activation and practical standing in response to mycobacterial an infection and stimulation with M. tb antigen Rv3416. Inhibiting Bcl2 generated protecting responses together with elevated expression of co-stimulatory molecules, oxidative burst, pro-inflammatory cytokine expression and autophagy. Lastly, co-culturing human PBMCs and BMDCs with antigen-primed T cells elevated their proliferation, activation and effector operate. These outcomes level in the direction of a essential function for Bcl2 in regulating BMDCs protection responses to mycobacterial an infection.
Key phrases: Autophagy; Bacterial burden; Bcl2; Immune responses; M. bovis BCG.
Platinum complexes inhibit HER-2 enriched and triple-negative breast most cancers cells metabolism to suppress development, stemness and migration by concentrating on PKM/LDHA and CCND1/BCL2/ATG3 signaling pathways
Triple-negative-breast most cancers (TNBC) and HER-2 enriched optimistic aggressive sorts of breast most cancers and are extremely metastatic in nature. Anticancer brokers these goal TNBC and HER-2 enriched optimistic breast cancers are thought-about necessary within the subject of breast most cancers analysis. Looking for the efficient anticancer brokers, we synthesized Pt(II) complexes to focus on these cancers. Platinum complexes (C1-C8) had been ready in single step by the response of commercially out there Ok2PtCl4 with the readily ready ligands (L1-L8). All these compounds had been characterised efficiently by completely different spectroscopic and spectrophotometric analyses.
Buildings of C1, C3 and C8 had been characterised by single crystal X-ray evaluation that confirmed the precise chelation mode of the SNO-triply coordinated ligand. All these complexes inhibited the in vitro development of MCF-7 (luminal-like), MDA-MB-231 (TNBC) and SKBR3 (HER-2 enriched) breast most cancers cells. C1, C3 and C7 induced cell loss of life and suppressed the clonogenic potential of those most cancers cells. Importantly, C1, C3 and C7 confirmed potentials to suppress most cancers stem cells/mammosphere formation and cell migration potential of MDA-MB-231 and SKBR3 breast most cancers cells.
These complexes additionally induced mobile senescence in MDA-MB-231 and SKBR3 cells, thus suggesting a cell retardation mechanism. Equally, these complexes induced DNA harm by activating p-H2AX expression and promoted autophagy through ATG3/LC3B axis activation in MDA-MB-231 and SKBR3 cells. Moreover, these complexes decreased the expression of oncogenic proteins similar to BCL2 and cylin-D1 these are concerned in most cancers cell survival and cell cycle development. To additional acquire perception, we discovered that C1 and C7 focused glycolytic pathways by regulating PKM and LDHA expression, that are concerned in glycolysis.
Furthermore, C1 and C7 suppressed the formation of ATP manufacturing that’s required for most cancers cell development. Taken collectively, the straightforward synthesis and organic assays outcomes level in the direction of the significance of those complexes in MDA-MB-231 (TNBC) and SKBR3 (HER-2 enriched) breast most cancers cells by concentrating on a number of signaling pathways these are thought-about necessary throughout breast most cancers development. This research produces bases for additional deeper in vitro or in vivo research that might result in the efficient breast most cancers brokers which we’re engaged on.
Results of low depth pulsed ultrasound on expression of B-cell lymphoma-2 and BCL2-Related X in untimely ovarian failure mice induced by 4-vinylcyclohexene diepoxide
Background: Untimely ovarian failure (POF) is a standard illness within the subject of Gynecology. Low depth pulsed ultrasound (LIPUS) can promote tissue restore and enhance operate. This research was carried out to find out the consequences of LIPUS on granulosa cells (GCs) apoptosis and protein expression of B-cell lymphoma-2 (Bcl-2) and BCL2-Related X (Bax) in 4-vinylcyclohexene diepoxide (VCD)-induced POF mice and examine the mechanisms of LIPUS on ovarian operate and reserve capability.
Strategies: The present POF mice mannequin was administrated with VCD (160 mg/kg) by intraperitoneal injection for 15 consecutive days. The mice had been divided into the POF group, LIPUS group and management group. Within the LIPUS group, the correct ovary of mice was handled by LIPUS (acoustic depth was 200 mW/cm2, frequency was 0.three MHz, and obligation cycle was 20%) for 20 min, 15 consecutive days from day 16. The mice of the POF group and management group had been handled with out ultrasonic output. The essential remark and physique weight had been recorded. Hematoxylin and eosin staining (H&E staining) and enzyme-linked immunosorbent assay (ELISA) had been utilized to detect ovarian follicle improvement, ovarian morphology and intercourse hormone secretion. Ovarian GCs apoptosis was detected by TUNEL assay and immunohistochemistry.
Outcomes: The outcomes confirmed that VCD can induce estrus cycle dysfunction, follicular atresia, intercourse hormone secretion decreased and GCs apoptosis in mice to ascertain POF mannequin efficiently. LIPUS considerably promoted follicular improvement, elevated intercourse hormone secretion, inhibited extreme follicular atresia and GCs apoptosis. The mechanism could be achieved by growing the protein expression of Bcl-2 and lowering the expression of Bax in ovaries.
Conclusions: LIPUS can enhance the POF induced by VCD. These findings have the potential to supply novel methodological basis for the long run analysis, which assist deal with POF sufferers within the clinic.
Key phrases: Apoptosis; Bax and Bcl-2; LIPUS; POF; VCD.
) Recombinant Human Bcl-2-like Protein 11/BIML (N-6His) |
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| CR24-1mg | Novoprotein | 1mg | EUR 2983.2 |
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Description: Supplied as a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, 10% glycerol, 2mM DTT, pH8.0 |
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Recombinant Human Bcl-2-like Protein 11/BIML (N-6His) |
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| CR24-500ug | Novoprotein | 500ug | EUR 1935.6 |
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Description: Supplied as a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, 10% glycerol, 2mM DTT, pH8.0 |
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Recombinant Human Bcl-2-like Protein 11/BIML (N-6His) |
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| CR24-50ug | Novoprotein | 50ug | EUR 595.2 |
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Description: Supplied as a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, 10% glycerol, 2mM DTT, pH8.0 |
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) ELISA kit for Rat Bcl-2-like protein 11 (BIM) |
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| KTE101123-48T | Abbkine | 48T | EUR 424.8 |
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Description: Quantitative sandwich ELISA for measuring Rat Bcl-2-like protein 11 (BIM) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Rat Bcl-2-like protein 11 (BIM) |
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| KTE101123-5platesof96wells | Abbkine | 5 plates of 96 wells | EUR 2702.4 |
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Description: Quantitative sandwich ELISA for measuring Rat Bcl-2-like protein 11 (BIM) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Rat Bcl-2-like protein 11 (BIM) |
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| KTE101123-96T | Abbkine | 96T | EUR 686.4 |
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Description: Quantitative sandwich ELISA for measuring Rat Bcl-2-like protein 11 (BIM) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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 Recombinant Human Bcl-2-like protein 11 Protein, His, Yeast-100ug |
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| QP5712-ye-100ug | EnQuireBio | 100ug | EUR 576 |
 Recombinant Human Bcl-2-like protein 11 Protein, His, Yeast-10ug |
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| QP5712-ye-10ug | EnQuireBio | 10ug | EUR 283.2 |
 Recombinant Human Bcl-2-like protein 11 Protein, His, Yeast-1mg |
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| QP5712-ye-1mg | EnQuireBio | 1mg | EUR 2262 |
 Recombinant Human Bcl-2-like protein 11 Protein, His, Yeast-200ug |
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| QP5712-ye-200ug | EnQuireBio | 200ug | EUR 892.8 |
 Recombinant Human Bcl-2-like protein 11 Protein, His, Yeast-500ug |
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| QP5712-ye-500ug | EnQuireBio | 500ug | EUR 1447.2 |
 Recombinant Human Bcl-2-like protein 11 Protein, His, Yeast-50ug |
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| QP5712-ye-50ug | EnQuireBio | 50ug | EUR 358.8 |
 CLIA Kit) Human Bcl-2 Like Protein 11 (Bcl2L11) CLIA Kit |
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| abx196479-96tests | Abbexa | 96 tests | EUR 990 |
 ELISA kit) Human Bcl-2-like protein 11(BCL2L11) ELISA kit |
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| CSB-EL002615HU-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
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Description: Quantitativesandwich ELISA kit for measuring Human Bcl-2-like protein 11 (BCL2L11) in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
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Human Bcl-2-like protein 11(BCL2L11) ELISA kit |
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| 1-CSB-EL002615HU | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human Bcl-2-like protein 11(BCL2L11) in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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 ELISA kit) Rabbit Bcl 2 like protein 11(BCL2L11) ELISA kit |
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| E04B0766-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Rabbit Bcl 2 like protein 11(BCL2L11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rabbit Bcl 2 like protein 11(BCL2L11) ELISA kit |
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| E04B0766-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Rabbit Bcl 2 like protein 11(BCL2L11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rabbit Bcl 2 like protein 11(BCL2L11) ELISA kit |
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| E04B0766-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Rabbit Bcl 2 like protein 11(BCL2L11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA Kit) Human Bcl2L11(Bcl-2 Like Protein 11) ELISA Kit |
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| EH2699 | FN Test | 96T | EUR 628.92 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.188 ng/ml |
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 ELISA kit) Pig Bcl 2 like protein 11(BCL2L11) ELISA kit |
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| E07B0766-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Porcine Bcl 2 like protein 11(BCL2L11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig Bcl 2 like protein 11(BCL2L11) ELISA kit |
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| E07B0766-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Porcine Bcl 2 like protein 11(BCL2L11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig Bcl 2 like protein 11(BCL2L11) ELISA kit |
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| E07B0766-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Porcine Bcl 2 like protein 11(BCL2L11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Human Bcl 2 like protein 11(BCL2L11) ELISA kit |
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| E01B0766-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Human Bcl 2 like protein 11(BCL2L11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Bcl 2 like protein 11(BCL2L11) ELISA kit |
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| E01B0766-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Human Bcl 2 like protein 11(BCL2L11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Bcl 2 like protein 11(BCL2L11) ELISA kit |
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| E01B0766-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Human Bcl 2 like protein 11(BCL2L11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Goat Bcl 2 like protein 11(BCL2L11) ELISA kit |
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| E06B0766-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Goat Bcl 2 like protein 11(BCL2L11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Bcl 2 like protein 11(BCL2L11) ELISA kit |
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| E06B0766-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Goat Bcl 2 like protein 11(BCL2L11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Bcl 2 like protein 11(BCL2L11) ELISA kit |
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| E06B0766-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Goat Bcl 2 like protein 11(BCL2L11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Mouse Bcl 2 like protein 11(BCL2L11) ELISA kit |
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| E03B0766-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Mouse Bcl 2 like protein 11(BCL2L11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Bcl 2 like protein 11(BCL2L11) ELISA kit |
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| E03B0766-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Mouse Bcl 2 like protein 11(BCL2L11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Bcl 2 like protein 11(BCL2L11) ELISA kit |
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| E03B0766-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Mouse Bcl 2 like protein 11(BCL2L11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Dog Bcl 2 like protein 11(BCL2L11) ELISA kit |
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| E08B0766-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Canine Bcl 2 like protein 11(BCL2L11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Dog Bcl 2 like protein 11(BCL2L11) ELISA kit |
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| E08B0766-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Canine Bcl 2 like protein 11(BCL2L11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Dog Bcl 2 like protein 11(BCL2L11) ELISA kit |
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| E08B0766-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Canine Bcl 2 like protein 11(BCL2L11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 Mouse Bcl- 2- like protein 11, Bcl2l11 ELISA KIT |
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| ELI-24063m | Lifescience Market | 96 Tests | EUR 1038 |
 Human Bcl- 2- like protein 11, BCL2L11 ELISA KIT |
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| ELI-34221h | Lifescience Market | 96 Tests | EUR 988.8 |
 ELISA kit) Monkey Bcl 2 like protein 11(BCL2L11) ELISA kit |
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| E09B0766-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Monkey Bcl 2 like protein 11(BCL2L11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Monkey Bcl 2 like protein 11(BCL2L11) ELISA kit |
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| E09B0766-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Monkey Bcl 2 like protein 11(BCL2L11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Monkey Bcl 2 like protein 11(BCL2L11) ELISA kit |
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| E09B0766-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Monkey Bcl 2 like protein 11(BCL2L11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 Recombinant Human Bcl-2-like protein 11 Protein, His-SUMO, E.coli-100ug |
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| QP5712-ec-100ug | EnQuireBio | 100ug | EUR 489.6 |
 Recombinant Human Bcl-2-like protein 11 Protein, His-SUMO, E.coli-10ug |
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| QP5712-ec-10ug | EnQuireBio | 10ug | EUR 240 |
 Recombinant Human Bcl-2-like protein 11 Protein, His-SUMO, E.coli-1mg |
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| QP5712-ec-1mg | EnQuireBio | 1mg | EUR 1958.4 |
 Recombinant Human Bcl-2-like protein 11 Protein, His-SUMO, E.coli-200ug |
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| QP5712-ec-200ug | EnQuireBio | 200ug | EUR 760.8 |
 Recombinant Human Bcl-2-like protein 11 Protein, His-SUMO, E.coli-500ug |
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| QP5712-ec-500ug | EnQuireBio | 500ug | EUR 1272 |
 Recombinant Human Bcl-2-like protein 11 Protein, His-SUMO, E.coli-50ug |
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| QP5712-ec-50ug | EnQuireBio | 50ug | EUR 315.6 |
) CLIA kit for Human Bcl2L11 (Bcl-2 Like Protein 11) |
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| E-CL-H0450 | Elabscience Biotech | 1 plate of 96 wells | EUR 700.8 |
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Description: A sandwich CLIA kit for quantitative measurement of Human Bcl2L11 (Bcl-2 Like Protein 11) in samples from Serum, Plasma, Cell supernatant |
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) ELISA kit for Human Bcl2L11 (Bcl-2 Like Protein 11) |
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| E-EL-H0582 | Elabscience Biotech | 1 plate of 96 wells | EUR 640.8 |
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Description: A sandwich ELISA kit for quantitative measurement of Human Bcl2L11 (Bcl-2 Like Protein 11) in samples from Serum, Plasma, Cell supernatant |
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 ELISA kit) Guinea pig Bcl 2 like protein 11(BCL2L11) ELISA kit |
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| E05B0766-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Guinea pig Bcl 2 like protein 11(BCL2L11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Guinea pig Bcl 2 like protein 11(BCL2L11) ELISA kit |
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| E05B0766-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Guinea pig Bcl 2 like protein 11(BCL2L11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Guinea pig Bcl 2 like protein 11(BCL2L11) ELISA kit |
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| E05B0766-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Guinea pig Bcl 2 like protein 11(BCL2L11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 Anti-Bcl-2/BCL2 Antibody |
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| A00040-2 | BosterBio | 100ug/vial | EUR 400.8 |
 Recombinant Human GDF-11 Protein |
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| PROTO95390-2 | BosterBio | 20ug | EUR 380.4 |
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Description: GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves arrest of progenitor cell-cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their amino acid sequence, suggests that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same. Recombinant human GDF-11 is a 25.0 kDa disulfide-linked homodimer containing two 109 amino acid polypeptide chains. It is highly homologous to myostatin/GDF-8 sharing 90% amino-acid sequence identity. |
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 Recombinant Human IL-11 Protein |
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| PROTP20809-2 | BosterBio | 10ug | EUR 380.4 |
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Description: IL-11 is a multifunctional cytokine produced by stromal cells such as fibroblasts, epithelial cells and osteoclasts. It is expressed in a wide variety of tissues including thymus, lung, bone, connective tissue and central nervous system. IL-11 plays an important regulatory role in hematopoiesis by stimulating growth of myeloid, erythroid and megakaryocyte progenitor cells. It also regulates bone metabolism, inhibits production of proinflammatory cytokines and protects against gastromucosal injury. Recombinant Human IL-11 is a 19.3 kDa protein consisting of 179 amino acid residues. |
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 Anti-Bcl-2 Rabbit Monoclonal Antibody |
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| M00040-2 | BosterBio | 100ug/vial | EUR 476.4 |
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Description: Rabbit Monoclonal Bcl-2 Antibody. Validated in IF, WB and tested in Human, Mouse. |
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 ELISA kit) Rat Bcl 2 like protein 2(BCL2L2) ELISA kit |
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| E02B0769-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Rat Bcl 2 like protein 2(BCL2L2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Bcl 2 like protein 2(BCL2L2) ELISA kit |
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| E02B0769-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Rat Bcl 2 like protein 2(BCL2L2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Bcl 2 like protein 2(BCL2L2) ELISA kit |
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| E02B0769-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Rat Bcl 2 like protein 2(BCL2L2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 Antibody) Bcl-2-Like Protein 2 (BCL2L2) Antibody |
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| 20-abx109264 | Abbexa |
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) Human Bcl-2-like protein 2 (BCL2L2) |
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| 1-CSB-EP821707HU | Cusabio |
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Description: Recombinant Human Bcl-2-like protein 2(BCL2L2) expressed in E.coli |
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 Bcl-2-like protein 12 antibody |
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| 22281-100ul | SAB | 100ul | EUR 468 |
 GFR alpha-like Recombinant Protein |
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| 11-410 | ProSci | 0.1 mg | EUR 714.3 |
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Description: GFR alpha-like is also known as GDNF family receptor alpha-like, GFRAL, C6orf144, UNQ9356, PRO34128. Growth differentiation factor-15 (GDF15) is a circulating protein that has been implicated in multiple biological processes, including energy homeostasis, body weight regulation, and cachexia driven by cancer and chronic disease. GDNF family receptor α-like (GFRAL) was recently identified as the neuronal brainstem receptor responsible for mediating the anorectic actions of GDF15. Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways. |
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 Antibody) Human Bcl-2-like Protein 2 (BCL2L2) Antibody |
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| 32113-05111 | AssayPro | 150 ug | EUR 313.2 |
 ELISA kit) Rat Bcl 2 like protein 1(BCL2L1) ELISA kit |
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| E02B0764-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Rat Bcl 2 like protein 1(BCL2L1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Bcl 2 like protein 1(BCL2L1) ELISA kit |
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| E02B0764-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Rat Bcl 2 like protein 1(BCL2L1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Bcl 2 like protein 1(BCL2L1) ELISA kit |
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| E02B0764-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Rat Bcl 2 like protein 1(BCL2L1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Rat Bcl 2 like protein 10(BCL2L10) ELISA kit |
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| E02B0765-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Rat Bcl 2 like protein 10(BCL2L10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Bcl 2 like protein 10(BCL2L10) ELISA kit |
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| E02B0765-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Rat Bcl 2 like protein 10(BCL2L10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Bcl 2 like protein 10(BCL2L10) ELISA kit |
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| E02B0765-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Rat Bcl 2 like protein 10(BCL2L10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Rat Bcl 2 like protein 13(BCL2L13) ELISA kit |
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| E02B0767-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Rat Bcl 2 like protein 13(BCL2L13) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Bcl 2 like protein 13(BCL2L13) ELISA kit |
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| E02B0767-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Rat Bcl 2 like protein 13(BCL2L13) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Bcl 2 like protein 13(BCL2L13) ELISA kit |
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| E02B0767-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Rat Bcl 2 like protein 13(BCL2L13) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Rat Bcl 2 like protein 15(BCL2L15) ELISA kit |
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| E02B0768-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Rat Bcl 2 like protein 15(BCL2L15) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Bcl 2 like protein 15(BCL2L15) ELISA kit |
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| E02B0768-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Rat Bcl 2 like protein 15(BCL2L15) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Bcl 2 like protein 15(BCL2L15) ELISA kit |
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| E02B0768-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Rat Bcl 2 like protein 15(BCL2L15) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 Bcl-2/ Rat Bcl- 2 ELISA Kit |
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| ELA-E0778r | Lifescience Market | 96 Tests | EUR 1063.2 |
 Bcl-2-like protein 1 Monoclonal Antibody |
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| 42016-100ul | SAB | 100ul | EUR 399.6 |
 Antibody) Bcl-2-Like Protein 15 (BCL2L15) Antibody |
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| 20-abx005400 | Abbexa |
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Bcl-2-Like Protein 15 (BCL2L15) Antibody |
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| 20-abx006283 | Abbexa |
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 Antibody) Bcl-2-Like Protein 1 (BCL2L1) Antibody |
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| 20-abx000597 | Abbexa |
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Bcl-2-Like Protein 15 (BCL2L15) Antibody |
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| abx122184-100ug | Abbexa | 100 ug | EUR 469.2 |
Bcl-2-Like Protein 1 (BCL2L1) Antibody |
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| 20-abx109263 | Abbexa |
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Bcl-2-Like Protein 1 (BCL2L1) Antibody |
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| abx116988-100ug | Abbexa | 100 ug | EUR 560.4 |
 Antibody) Bcl-2-Like Protein 12 (BCL2L12) Antibody |
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| 20-abx014252 | Abbexa |
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Bcl-2-Like Protein 1 (BCL2L1) Antibody |
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| abx034903-400ul | Abbexa | 400 ul | EUR 627.6 |
Bcl-2-Like Protein 1 (BCL2L1) Antibody |
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| abx034903-80l | Abbexa | 80 µl | EUR 343.2 |
Bcl-2-Like Protein 12 (BCL2L12) Antibody |
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| abx030793-400ul | Abbexa | 400 ul | EUR 627.6 |
Bcl-2-Like Protein 12 (BCL2L12) Antibody |
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| abx030793-80l | Abbexa | 80 µl | EUR 343.2 |
Bcl-2-Like Protein 1 (BCL2L1) Antibody |
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| 20-abx210144 | Abbexa |
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Bcl-2-Like Protein 15 (BCL2L15) Antibody |
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| 20-abx320802 | Abbexa |
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Bcl-2-Like Protein 1 (BCL2L1) Antibody |
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| abx230842-100ug | Abbexa | 100 ug | EUR 610.8 |
Bcl-2-Like Protein 1 (BCL2L1) Antibody |
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| abx230843-100ug | Abbexa | 100 ug | EUR 577.2 |
Bcl-2-Like Protein 12 (BCL2L12) Antibody |
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| abx230845-100ug | Abbexa | 100 ug | EUR 577.2 |
Bcl-2-Like Protein 15 (BCL2L15) Antibody |
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| abx432400-200ul | Abbexa | 200 ul | EUR 343.2 |
Bcl-2-Like Protein 15 (BCL2L15) Antibody |
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| abx432401-200ul | Abbexa | 200 ul | EUR 343.2 |
) Human Bcl-2-like protein 1 (BCL2L1) |
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| 1-CSB-EP002613HU | Cusabio |
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Description: Recombinant Human Bcl-2-like protein 1(BCL2L1),partial expressed in E.coli |
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) Human Bcl-2-like protein 15 (BCL2L15) |
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| 1-CSB-EP719420HU | Cusabio |
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Description: Recombinant Human Bcl-2-like protein 15(BCL2L15) expressed in E.coli |
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ELISA Kit) Rat Bcl-2-like protein 1(Bcl2-L-1/Bcl-X)ELISA Kit |
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| CSB-E13604r-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
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Description: Quantitativesandwich ELISA kit for measuring Rat Bcl-2-like protein 1 (Bcl2-L-1/Bcl-X) in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
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