Category: Exosomes
Simultaneous Expression of Th1- and Treg-Associated Chemokine Genes and CD4 +, CD8 +, and Foxp3 + Cells in the Premalignant Lesions of 4NQO-Induced Mouse Tongue Tumorigenesis
Chemokines and cytokines in the tumor microenvironment influence immune cell infiltration and activation. To elucidate their role in immune cell recruitment during oral cancer development, we generated a mouse tongue cancer model using the carcinogen 4-nitroquinoline 1-oxide (4NQO) and investigated the carcinogenetic process and chemokine/cytokine gene expression kinetics in the mouse tongue. C57/BL6 mice were…
Read MoreProseek single-plex protein assay kit system to detect sAxl and Gas6 in serological material of brain tumor patients
The receptor tyrosine kinase (RTK) Axl and its ligand Gas6 are critically involved in the pathogenesis of high-grade glioma (HGG). Both proteins were found to be overexpressed e.g. in tumor cells, mediating cell proliferation and migration as well as tumor angiogenesis and neuroinflammation. The extracellular domain of Axl (sAxl) and Gas6 were found in the…
Read MoreNeuroinflammation and Neutrophils: Modulation by Ouabain
Cardiotonic steroids are pure compounds that current many physiological and pharmacological capabilities. They bind Na+/Ok+-ATPase (NKA) modifying mobile ion focus and set off cell signaling mechanisms with out altering ion stability. These steroids are recognized to modulate some immune responses, together with cytokine manufacturing, neutrophil migration, and irritation (peripherally and within the nervous system). Irritation…
Read MoreBilirubin binding properties of pigeon serum albumin and its comparison with human serum albumin
Binding of bilirubin (BR) to pigeon serum albumin (PgSA) was studied by absorption, fluorescence and CD spectroscopy and outcomes had been in contrast with these obtained with human serum albumin (HSA). PgSA was discovered to be structurally just like HSA as judged by near- and far-UV CD spectra. Nonetheless, PgSA lacks tryptophan. Binding of BR…
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Trinity Biotech: Clinical Diagnostic
Trinity Biotech specializes within the growth, manufacture and advertising and marketing of diagnostic check kits. Our continued success relies on the very fact, that as an organization, we persistently obtain requirements of excellence within the high quality of all we do. The check kits we manufacture are used within the scientific laboratory and point-of-care segments of the…
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