immpact-international

Mycobacterium tuberculosis Exploits Focal Adhesion Kinase to Induce Necrotic Cell Death and Inhibit Reactive Oxygen Species Production

Tuberculosis is a lethal, contagious respiratory illness that’s attributable to the pathogenic bacterium Mycobacterium tuberculosis (Mtb). Mtb is adept at manipulating and evading host immunity by hijacking alveolar macrophages, the primary line of protection towards inhaled pathogens, by regulating the mode and timing of host cell loss of life. It’s established that Mtb an infection actively blocks…

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immpact-international

BCL2 Expression in First-Line Diffuse Large B-Cell Lymphoma Identifies a Patient Population With Poor Prognosis

Introduction: The prognostic worth of B-cell lymphoma 2 (BCL2) expression in de novo diffuse massive B-cell lymphoma (DLBCL) handled with immunochemotherapy is of curiosity to outline a goal affected person inhabitants for medical growth of BCL2 inhibitors. We aimed to develop a reproducible immunohistochemistry algorithm and assay to find out BCL2 protein expression and assess the…

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immpact-international

Combined p53 and Bcl2 Immunophenotypes in Prognosis of Vietnamese Invasive Breast Carcinoma: A Single Institutional Retrospective Analysis

Background: Aberrant of p53 and Bcl2 genes trigger adjustments within the amount and high quality of their proteins and contribute to the pathogenesis of some most cancers varieties together with breast most cancers. Expression of p53 and Bcl2 had been related to antagonistic medical outcomes in breast most cancers. Function: To foretell the survival outcomes of invasive…

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immpact-international

Precursor B-Cell Acute Lymphoblastic Leukemia With MYC and BCL2 Rearrangements Presenting as Extensive Extranodal Disease in an Adolescent

Mixed rearrangements of MYC and BCL2 are uncommon in precursor B-cell acute lymphoblastic leukemia (B-ALL). A 14-year-old boy offered with swelling of the knee and face. Imaging revealed diffuse infiltration of lacrimal glands, parotid glands together with the in depth epidural illness. Morphology and immunophenotype of knee joint aspirate have been in keeping with precursor…

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immpact-international

High-Grade B-cell lymphomas with MYC and BCL2 translocations lack tumor-associated macrophages and PD-L1 expression: A possible noninflamed subgroup

We investigated the intratumoral supply of PD-L1 expression and the infiltration of tumor-associated macrophages (TAMs) in giant B-cell lymphomas (LBCL) with or with out MYC-translocation, in addition to doable correlations to BCL2- and BCL6-translocations and cell of origin (COO). 126 affected person samples have been studied in a cohort enriched for MYC translocated tumors with…

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