immpact-international

Circular RNA SERPINE2 promotes development of glioblastoma by regulating the miR-361-3p/miR-324-5p/ BCL2 signaling pathway

Round RNA (circRNA) is a brand new kind of long-sequence RNA fashioned by a noncanonical type of different splicing referred to as back-splicing. Rising proof has revealed that circRNAs are concerned in most cancers development, regulating cancer-related genes via sponging microRNAs (miRNAs). In our examine, we recognized a novel upregulated circRNA, circSERPINE2, via analyzing circRNAs microarray knowledge of glioblastoma from GEO datasets (GSE146463). Quantitative real-time PCR was used to additional verify the upregulation of circSERPINE2 in glioblastoma cell strains and tissues. Silencing circSERPINE2 inhibits glioblastoma proliferation in vivo and in vitro via cell counting kit-8 (CCK-8) assay, colony formation assay, move cytometry evaluation, and western blot evaluation and xenograft tumor mannequin. Mechanistically, circSERPINE2 may straight sponge miR-324-5p and miR-361-3p. BCL2, referred to as a novel anti-apoptosis gene, is a goal gene each of miR-324-5p and miR-361-3p. Thus, circSERPINE2 promotes BCL2 expression via sponging miR-324-5p and miR-361-3p. In conclusion, our examine revealed the organic operate and mechanism of circSERPINE2 in glioblastoma development and that circSERPINE2 may very well be a possible therapeutic goal for glioblastoma.

Tanshinone I restrains osteosarcoma development by regulating circ_0000376/miR-432-5p/BCL2 axis

Round RNAs (circRNAs) have been recognized as necessary regulators in most cancers development. Nonetheless, little is understood concerning the organic operate of circ_0000376 within the development of osteosarcoma (OS). Cell viability, colony formation skill, apoptosis, and motility had been analyzed by Cell Counting Equipment-Eight assay, colony formation assay, move cytometry, and transwell assays. Mobile glycolytic metabolism was analyzed utilizing industrial kits. RT-qPCR and Western blot assay had been carried out to research RNA and protein expression in OS tissues and cells.
  • Starbase software program was used to ascertain circRNA-microRNA (miRNA)-messenger RNA linkage, and intermolecular interplay was verified by dual-luciferase reporter assay. Xenograft tumor assay was carried out to research the results of Tanshinone I (Tan I) and circ_0000376 on xenograft tumor development in vivo. Tan I remedy suppressed the viability, migration, invasion, and glycolysis and triggered the apoptosis of OS cells.
  • Tan I remedy markedly down-regulated circ_0000376 expression in OS cells. The addition of circ_0000376 plasmid largely rescued the malignant behaviors of OS cells upon Tan I publicity. Circ_0000376 interacted with miR-432-5p in OS cells. Circ_0000376 overexpression-mediated protecting results in Tan I-induced OS cells had been partly attenuated by the buildup of miR-432-5p.
  • miR-432-5p certain to the three’ untranslated area (3’UTR) of B-cell leukemia/lymphoma 2 (BCL2) in OS cells. miR-432-5p interference-induced results in Tan I-treated OS cells had been partly overturned by the silence of BCL2.
  • Circ_0000376 can act as miR-432-5p sponge to up-regulate BCL2 expression in OS cells. Circ_0000376 silencing contributed to the anti-tumor impact of Tan I on the expansion of xenograft tumors in vivo. Tan I exerted an anti-tumor function in OS development by focusing on circ_0000376/miR-432-5p/BCL2 axis.
Key phrases: BCL2; Osteosarcoma; Tanshinone I; circ_0000376; miR-432-5p.
immpact-international
immpact-international

Mettl3 inhibits the apoptosis and autophagy of chondrocytes in irritation via mediating Bcl2 stability through Ythdf1-mediated m 6 A modification

N6-methyladenosine (m6A) methylation is likely one of the commonest inner modifications in eukaryotic messenger RNA occurring on N6 nitrogen of adenosine. Nevertheless, the roles of m6A in temporomandibular joint osteoarthritis (TMJ OA) are nonetheless elusive. Right here, we examine the operate and mechanism of methyltransferase-like 3 (Mettl3) in chondrocytes in irritation. We discovered that the expression of Mettl3 decreased each in vivo TMJ OA mice and in vitro inflammatory stimulation. Functionally, loss and acquire research illustrated that Mettl3 inhibited the apoptosis and autophagy of chondrocytes induced by TNF-α stimulation in vitro. Mettl3 inhibitor, S-adenosylhomocysteine (SAH) promoted the apoptosis and autophagy of chondrocytes with irritation in vitro and aggravated the degeneration of chondrocytes and subchondral bone in monosodium iodoacetate (MIA) induced TMJ OA mice in vivo.
Mechanistically, the bioinformatics evaluation, m6A-RNA immunoprecipitation (MeRIP) and RNA immunoprecipitation (RIP) had been used to establish that Bcl2 mRNA was the downstream goal of Mettl3 for m6A modification. Moreover, the outcomes revealed that Yth m6A RNA binding protein 1 (Ythdf1) mediated the steadiness of Bcl2 mRNA catalyzed by Mettl3. Co-immunoprecipitation (Co-IP) confirmed that Bcl2 protein interacted with Beclin1 protein in chondrocytes induced by TNF-α stimulation. In conclusion, our findings establish that Mettl3 inhibits the apoptosis and autophagy of chondrocytes in irritation via m6A/Ythdf1/Bcl2 sign axis which gives promising therapeutic technique for TMJ OA.
Key phrases: Apoptosis; Autophagy; B-cell lymphoma 2; Chondrocyte; Irritation; Methyltransferase-like 3; N(6)-methyladenosine.’

BCL2 translocation in excessive grade B cell lymphoma (NOS, DH/TH) is related to diminished development free survival

Excessive Grade B Cell Lymphoma, NOS, and Excessive Grade B Cell Lymphoma with Twin Hit or Triple Hit have been lately recategorized within the 2016 revision of the WHO classification of lymphoid neoplasms. On this examine we have now characterised the genetic, histopathological, and medical options of a sequence of the sort of lymphoid neoplasia (17 HGBCL NOS and 53 HGBCL DH/TH).HGBCL NOS confirmed higher response to first line remedy than HGBCL with DH/TH however no important variations in PFS or OS had been discovered between the 2 classes.
Survival evaluation in the entire cohort of instances discovered that solely the presence of BCL2 translocation was considerably related to PFS. Different medical options similar to IPI, LDH or stage had been equal in each classes. Moreover, each excessive grade and DLBCL morphological patterns confirmed equal PFS and OS on this set of Excessive grade BCL NOS/DH/TH.Key factorsBCL2 translocation in Excessive Grade B Cell Lymphoma NOS and Excessive Grade B Cell Lymphoma with DH/TH is related to diminished development free survival.Each excessive grade and DLBCL morphological patterns confirmed equal end result relating to PFS and OS in HGBCL.

CRKLAIFM3AIFBCL2, and UBASH3A throughout Human Kidney Growth

We aimed to analyze the spatio-temporal expression of attainable CAKUT candidate genes CRKLAIFM3, and UBASH3A, in addition to AIF and BCL2 throughout human kidney growth. Human fetal kidney tissue was stained with antibodies and analyzed by fluorescence microscopy and RT-PCR. Quantification of constructive cells was assessed by calculation of space proportion and counting cells in nephron buildings. Outcomes confirmed statistically important variations within the temporal expression patterns of the examined markers, relying on the investigated developmental stage.
Restricted however sturdy expression of CRKL was seen in growing kidneys, with rising expression as much as the interval the place nearly all of nephrons are fashioned. Outcomes additionally lead us to conclude that AIFM3 and AIF are necessary for selling cell survival, however solely AIFM3 is taken into account a CAKUT candidate gene because of the lack of AIF in nephron developmental buildings.
Our findings suggest nice significance of AIFM3 in vitality manufacturing in nephrogenesis and tubular maturation. UBASH3A uncooked scores confirmed larger immunoreactivity in growing buildings than mature ones which might level to a significant function in nephrogenesis. The truth that mRNA and proteins of CRKLUBASH3A, and AIFM3 had been detected in all phases of kidney growth implies their function as renal growth management genes.

Mouse FGF-2 Recombinant Protein

R00121-2 5ug/vial
EUR 259
Description: FGF basic (FGF2) is a multipotential fibroblast growth factor that stimulates and supports proliferation, migration and differentiation. Mouse FGF basic (FGF-2) Recombinant Protein is purified FGF basic (FGF-2) produced in yeast.

Recombinant Human TFF-2 Protein

PROTQ03403-2 20ug
EUR 317
Description: The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are expressed in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF2 has been shown to inhibit gastrointestinal motility and gastric acid secretion. Recent data suggests a potential role for TFF2 in acute and chronic asthma (Nikolaidis, N.M. et al. Am. Journal Respir. Cell Mol. Biol. (2003) 4: 458-464). Recombinant human TFF2 is a 12.0 kDa polypeptide of 107 amino acid residues, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds.

Recombinant Human Relaxin-2 Protein

PROTP04090-2 25ug
EUR 317
Description: Relaxin-2 is a peptide hormone structurally related to insulin, which is expressed in the placenta, decidua, prostate, and in the ovary during pregnancy. Of the three known relaxin genes, Relaxin-2 is the only relaxin known to circulate in the blood. Relaxin-2 binds specifically to the LGR7 and LGR8 receptors, previously identified as an “orphan” G protein coupled receptors. Signaling by Relaxin-2 through its target receptors enhances the growth of pubic ligaments and ripening of the cervix during birth. Recombinant Relaxin-2 is a nonglycosylated 6.0 kDa disulfide linked heterodimeric protein consisting of a 24 amino acid A-chain and a 29 amino acid B-chain.

Recombinant Murine IL-2 Protein

PROTP04351-2 20ug
EUR 317
Description: IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant murine IL-2 is a 17.2 kDa protein, containing 149 amino acid residues.

Recombinant Human PAI-2 Protein

PROTP05120-2 10ug
EUR 317
Description: PAI-2 is an inhibitory serpin expressed mainly in keratinocytes, activated monocytes, and placental trophoblasts. It exists predominantly as a 47 kDa nonglycosylated intracellular protein which can be induced to be secreted as 60 kDa glycoprotein. The glycosylated and unglycosylated forms of PAI-2 are equally effective as inhibitors of urokinase-type plasminogen activator (uPA), the only established physiological target of this serpin. PAI-2 has a unique ability to form dormant polymers spontaneously and reversibly under physiological conditions. The physiological relevance of this property, which is neither a consequence of any mutation in the PAI-2 gene nor associated with any known disorder, is still unclear. However, it appears that the formation of intracellular dormant polymers may be important for the controlled release of the inhibitor from PAI-2 producing cells. Plasma levels of PAI-2 are usually low or undetectable, except during pregnancy and in some forms of monocytic leukemia. Secretion of PAI-2 from the placenta normally occurs during the third trimester of pregnancy and accounts for the dramatic increase in PAI-2 levels (up to 250 ng/ml), which are maintained at these levels until postpartum, and then rapidly decline. In addition to its vital role in protecting the placenta from degradation by uPA and/or uPA-activated proteases, PAI-2 has been shown to be essential for the prevention of metastatic spread of neck, lung and breast cancers. The beneficial effect of PAI-2 seen in these studies is presumed to stem from its ability to inhibit uPA-dependent cell dissemination. PAI-2 has also been reported to inhibit keratinocyte proliferation, and to participate in the innate immune response during viral infection. Recombinant human PAI-2 is a 415-residue nonglycosylated protein.

Recombinant Human MMP-2 Protein

PROTP08253-2 10ug
EUR 317
Description: Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-2 is a secreted collagenase with specificity toward Type IV, V, VII, and X collagens. Recombinant human MMP-2 is a 62.0 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (552 amino acids).

Chicken IL-2 Recombinant Protein

R00387-2 5ug/vial
EUR 259
Description: Interleukin-2 (IL-2) is a cytokine produced by T-helper cells in response to antigenic or mitogenic stimulation. It is required for T-cell proliferation and other activities crucial to the regulation of the immune response. Chicken IL-2 Recombinant Protein is purified interleukin-2 produced in yeast.

Recombinant Human BD-2 Protein

PROTO15263-2 20ug
EUR 317
Description: Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and in some cases, a propeptide sequence. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant human BD-2 is a 4.3 kDa protein containing 41 amino acid residues.

BMP-2 Bone Morphogenetic Protein-2 Human Recombinant Protein, Monomer

PROTP12643-2 Regular: 20ug
EUR 317
Description: Bone Morphogenetic Protein-2 Human Recombinant produced in E.Coli is a monomeric, non-glycosylated, Polypeptide chain containing 115 amino acids (283-396) and having a molecular mass of 13009 Dalton. ;The BMP-2 is purified by proprietary chromatographic techniques.

IL-2 Interleukin-2 Human Recombinant Protein, His Tag

PROTP60568-2 Regular: 10ug
EUR 317
Description: Interleukin-2 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 133 amino acids fragment (21-153) having a molecular weight of 20kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. _x000D_ The IL-2 His is purified by proprietary chromatographic techniques._x000D_

ErbB2 ErbB-2 Human Recombinant Protein

PROTP04626-2 Regular: 20ug
EUR 317
Description: ErbB-2 Human Recombinant is a 43.4 kDa protein containing 397 amino acid residues of the human Herstatin, and an extra Methionine at N-Terminal (underlined), produced in E.coli.

Recombinant Human TGF-Beta 2 (insect derived) Protein

PROTP61812-2 10ug
EUR 317
Description: The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development. Recombinant human TGF-β2 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.
* Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.

Nori® Mouse IL-2 ELISA Kit- 2 Plates

GR117024-2 2 x 96-well
EUR 832

Nori® Mouse IGFBP-2 ELISA Kit- 2 Plates

GR117043-2 2 x 96-well
EUR 832

AHSG Alpha-2-HS-Glycoprotein Human Recombinant Protein HEK

PROTP02765-2 Regular: 10ug
EUR 317
Description: AHSG Human Recombinant produced by transfected human cells is a single polypeptide chain containing 357 amino acids (19-367). AHSG is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

FGF-2 Fibroblast Growth Factor-Basic Human Recombinant Protein

PROTP09038-2 Regular: 50ug
EUR 317
Description: Fibroblast Growth Factor-2 Human Recombinant (FGF-2) produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 154 amino acids and having a molecular mass of 17.2kDa.;The FGF-b is purified by proprietary chromatographic techniques.

TIMP2 Tissue Inhibitor of Metalloprotease 2 Human Recombinant Protein

PROTP16035-2 Regular: 20ug
EUR 317
Description: TIMP2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 194 amino acids and having a molecular mass of 21.8kDa. 

Nori® Human Angiopoietin-Like 4 ELISA Kit (2 plates)

GR106246-2 2 x 96-well
EUR 832

PLGF2 Human, Placenta Growth Factor-2 Human Recombinant Protein, CHO

PROTP49763-2 Regular: 25ug
EUR 317
Description: PLGF2 Human Recombinant (19-170 a.a.) produced in CHO is a disulfide-linked homodimeric, glycosylated, polypeptide chain containing 152 amino acids and having a molecular mass of 33kDa.;The PLGF-2 Human Recombinant protein is purified by proprietary chromatographic techniques.

B2M Human, Beta 2 Microglobulin Human Recombinant Protein, His Tag

PROTP61769-2 Regular: 5ug
EUR 317
Description: B2M Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 120 amino acids (1-119 a.a.) and having a molecular mass of 14 kDa. The B2M is fused to a 21 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

LCN2 Neutrophil Gelatinase Associated Lipocalin/Lipocalin-2 Human Recombinant Protein

PROTP80188-2 Regular: 10ug
EUR 317
Description: LCN2 Human Recombinant produced in E.Coli is a homodimeric non-glycosylated polypeptide chains consisting of two 178 amino acids and having a molecular mass of 41.0kDa. 

TNFR2 Tumor Necrosis Factor Receptor Type 2 Human Recombinant Protein

PROTP20333-2 Regular: 20ug
EUR 317
Description: TNFR2 Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 184 amino acids and having a molecular mass of 20kDa. The TNFR2 is purified by proprietary chromatographic techniques.

Anti-Adiponectin Receptor 2 (mouse) Antibody

A02218-2 200ug
EUR 498
Description: Goat Polyclonal Adiponectin Receptor 2 (mouse) Antibody. Validated in IF, IHC and tested in Mouse.

2 x Protein Loading Buffer

GR103016-2 25 mL
EUR 89

Human Bcl-2-like protein 2 (BCL2L2)

1-CSB-EP821707HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Bcl-2-like protein 2(BCL2L2) expressed in E.coli

Bcl-2-Like Protein 2 (BCL2L2) Antibody

20-abx109264
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Nori® Human Angiopoietin-2 (ANG-2) ELISA Kit (2 plates)

GR106245-2 2 x 96-well
EUR 832

Nori Equine MMP-2/TIMP-2 Complex ELISA Kit (2 plates)

GR106502-2 2 x 96-well
EUR 832

DCTN2 (1-403) Dynactin 2 (1-403 a.a.) Human Recombinant Protein

PROTQ13561-2 Regular: 20ug
EUR 317
Description: Dynactin 2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 426 amino acids (1-403 a.a) and having a molecular mass of 46.9kDa.;DCTN2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

RARRES2 Human, Retinoic Acid Receptor Responder 2 Human Recombinant Protein,Sf9

PROTQ99969-2 Regular: 5ug
EUR 317
Description: RARRES2 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 146 amino acids (21-157a.a.) and having a molecular mass of 16.9kDa. (Molecular size on SDS-PAGE will appear at approximately 18-28kDa). RARRES2 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Mouse Bcl- 2- like protein 2, Bcl2l2 ELISA KIT

ELI-11430m 96 Tests
EUR 865

Mouse Bcl 2 like protein 2(BCL2L2) ELISA kit

E03B0769-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse Bcl 2 like protein 2(BCL2L2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Bcl 2 like protein 2(BCL2L2) ELISA kit

E03B0769-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse Bcl 2 like protein 2(BCL2L2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Bcl 2 like protein 2(BCL2L2) ELISA kit

E03B0769-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Bcl 2 like protein 2(BCL2L2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

2-Propyl-β-D-glucuronide, 2 mg

0904-2 2 mg
EUR 162

Nori® Human b-defensin 2 (BD-2) ELISA Kit- 2 Plates

GR111099-2 2 x 96-well
EUR 832

Nori® Human MMP-2/TIMP-2 Complex ELISA Kit (2 plates)

GR106372-2 2 x 96-well
EUR 832

Mouse Pancreas PrimaCell 2: Pancreatic Epithelial Cells

2-82102 1 Kit Ask for price

Mouse CCL3 Recombinant Protein

R00405-2 5ug/vial
EUR 259
Description: Chemokine ligand 3 (CCL3), also known as Macrophage inflammatory protein-1 alpha (MIP-1 alpha) is a small cytokine belonging to the CC chemokine family. CCL3/MIP-1 alpha is a chemoattractant for several different leukocytes, with varying degrees of potency (monocytes = T-cells>neutrophils>eosinophils).

Mouse APRIL Recombinant Protein

R02417-2 5ug/vial
EUR 259
Description: A proliferation-inducing ligand (APRIL), also known as TNFSF13, is a member of the tumor necrosis factor (TNF) ligand superfamily. APRIL/TNFSF13 has been shown to play a role in protecting cells from undergoing apoptosis and promoting B cell development. Mouse APRIL Recombinant Protein is purified APRIL (TNFSF13) produced in yeast.

a.a.), TRAIL/APO 2 Ligand (114-281 a.a.) Human Recombinant Protein, Active

PROTP50591-2 Regular: 10ug
EUR 317
Description: Soluble TNF-related apoptosis-inducing ligand Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 169 amino acids _x000D_ (114-281) and having a molecular mass of 19.6 kDa._x000D_ The sTRAIL is purified by proprietary chromatographic techniques.

Anti-Bcl-10 Monoclonal Antibody (Carmen-1)

M01616-2 100ug
EUR 397
Description: Rat Monoclonal Bcl-10 Antibody (Carmen-1). Validated in IHC, WB and tested in Human, Mouse.

Nori Human TIM-2 ELISA Kit-2 Plates

GR111039-2 2 x 96-well
EUR 832

Nori Equine MMP-2 ELISA Kit-2 Plates

GR106478-2 2 x 96-well
EUR 832

Nori Equine TIM-2 ELISA Kit (2 plates)

GR106516-2 2 x 96-well
EUR 832

Nori Canine TIM-2 ELISA Kit (2 plates)

GR115041-2 2 x 96-well
EUR 832

2 M NaCl

GR103063-2 200 mL
EUR 59

Nori® Mouse TGFb1 ELISA Kit- 2 Plates

GR117005-2 2 x 96-well
EUR 832

Nori® Mouse TGFb2 ELISA Kit- 2 Plates

GR117006-2 2 x 96-well
EUR 832

Nori® Mouse TGFb3 ELISA Kit- 2 Plates

GR117007-2 2 x 96-well
EUR 832

Nori® Mouse gp130 ELISA Kit (2 plates)

GR106287-2 2 x 96-well
EUR 832

Nori® Mouse Thrombopoietin ELISA Kit (2 plates)

GR106417-2 2 x 96-well
EUR 832

Nori® Mouse Erythropoietin ELISA Kit (2 plates)

GR106432-2 2 x 96-well
EUR 832

SOX2 Human, SRY (sex determining region Y)-box 2 Human Recombinant Protein, TAT

PROTP48431-2 Regular: 25ug
EUR 317
Description: Sox2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 330 amino acids (317 aa residues of the full length Sox2) and having a molecular mass of 36kDa.;Sox2 is fused to a 13 amino acid TAT peptide at C-terminus (GGYGRKKRRQRRR) & purified by proprietary chromatographic techniques.

VEGFR2-Fc Vascular Endothelial Growth Factor Receptor-2 Fc Chimera Human Recombinant Protein

PROTP35968-2 Regular: 10ug
EUR 317
Description: Soluble VEGFR2 Fc Human Recombinant fused with the Fc part of human IgG1 produced in baculovirus is a disulfide-linked homodimeric, glycosylated, polypeptide containing 968 amino acids and having a molecular mass of 145 kDa. The soluble receptor protein contains only the first 7 extracellular domains, which contain all the information necessary for ligand binding.

Nori® Rabbit IL-2 ELISA Kit- 2 Plates

GR144032-2 2 x 96-well
EUR 832

Nori® Monkey IL-2 ELISA Kit- 2 Plates

GR169004-2 2 x 96-well
EUR 832

Nori® Donkey IL-2 ELISA Kit- 2 Plates

GR170004-2 2 x 96-well
EUR 832

Nori® Porcine MMP-2 ELISA Kit- 2 Plates

GR113006-2 2 x 96-well
EUR 832

Nori® Chicken Netrin-2 ELISA Kit (2 plates)

GR106184-2 2 x 96-well
EUR 832

Nori® Human Tie-2 ELISA Kit (2 plates)

GR106458-2 2 x 96-well
EUR 832

Nori® Human TIMP-2 ELISA Kit (2 plates)

GR106460-2 2 x 96-well
EUR 832

Nori® Human Trappin-2 ELISA Kit (2 plates)

GR106467-2 2 x 96-well
EUR 832

Nori® Chicken MMP-2 ELISA Kit- 2 Plates

GR114008-2 2 x 96-well
EUR 832

Nori® Chicken IGFBP-2 ELISA Kit-2 Plates

GR114026-2 2 x 96-well
EUR 832

ENO2 Neurone Specific Enolase 2 Human protein

PROTP09104-2 Regular: 20ug
EUR 317
Description: Human Neurone Specific Enolase produced in Human CNS having a molecular mass of 45kDa.

Bcl-2-like protein 12 antibody

22281-100ul 100ul
EUR 390

Mouse IL-18 Recombinant Protein

R00124-2 5ug/vial
EUR 259
Description: Interleukin-18 (IL-18) is a proinflammatory cytokine that belongs to the IL-1 superfamily. IL-18 works together with IL-12 to induce cell-mediated immunity following infection, and IL-18 is also able to induce severe inflammatory reactions, which suggests its role in certain inflammatory disorders. Mouse IL-18 Recombinant Protein is purified interleukin-18 produced in yeast.

Mouse IFN beta Recombinant Protein

R02041-2 5ug/vial
EUR 259
Description: IFN beta is a mammalian Type I inferferon, functionig as a regulator of cellular activity by interacting with cell-surface receptors and activating various signaling pathways. IFN beta produces antiviral, antibacterial, and anticancer properties. Mouse IFN beta Recombinant Protein is purified IFN beta produced in yeast.

ANGPTL3 (243-460) Angiopoietin-like Protein 3 (243-460 a.a.) Human Recombinant Protein

PROTQ9Y5C1-2 Regular: 20ug
EUR 317
Description: ANGPTL3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 239 amino acids (243-460 a.a) and having a molecular mass of 27.7kDa. ANGPTL3 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Acrp30 Mouse, Adiponectin Mouse Recombinant Protein, HEK

PROTQ60994-2 Regular: 10ug
EUR 317
Description: The Acrp30 Mouse Recombinant is fused with FLAG tag having a total Mw of 26kDa.

Human Bcl-2-like Protein 2 (BCL2L2) Antibody

32113-05111 150 ug
EUR 261

Nori® Guinea Pig IL-2 ELISA Kit- 2 Plates

GR171004-2 2 x 96-well
EUR 832

Nori® Porcine b-defensin 2 ELISA Kit- 2 Plates

GR113081-2 2 x 96-well
EUR 832

Nori® Canine (dog) IL-2 ELISA Kit (2 plates)

GR106163-2 2 x 96-well
EUR 832

Nori® Porcine (pig) IL-2 ELISA Kit (2 plates)

GR106188-2 2 x 96-well
EUR 832

PG LIVER 2 EA*

59423-2 2 EA
EUR 192.24

Individual Reaction Mix 2

G065-2 200 reactions
EUR 167

Nori® Mouse PDGF-AA ELISA Kit- 2 Plates

GR117008-2 2 x 96-well
EUR 832

Nori® Mouse PDGF-BB ELISA Kit- 2 Plates

GR117009-2 2 x 96-well
EUR 832

Nori® Mouse PDGF-AB ELISA Kit- 2 Plates

GR117010-2 2 x 96-well
EUR 832

Nori® Mouse TIM-5 ELISA Kit- 2 Plates

GR117011-2 2 x 96-well
EUR 832

Nori® Mouse TIM-6 ELISA Kit- 2 Plates

GR117012-2 2 x 96-well
EUR 832

Nori® Mouse IL-1b ELISA Kit- 2 Plates

GR117023-2 2 x 96-well
EUR 832

Nori® Mouse IL-8 ELISA Kit- 2 Plates

GR117025-2 2 x 96-well
EUR 832

Nori® Mouse IL-10 ELISA Kit- 2 Plates

GR117026-2 2 x 96-well
EUR 832

Nori® Mouse IL-12 ELISA Kit- 2 Plates

GR117027-2 2 x 96-well
EUR 832

Nori® Mouse IL-15 ELISA Kit- 2 Plates

GR117029-2 2 x 96-well
EUR 832

Nori® Mouse IL-21 ELISA Kit- 2 Plates

GR117031-2 2 x 96-well
EUR 832

Nori® Mouse IL-5 ELISA Kit- 2 Plates

GR117032-2 2 x 96-well
EUR 832