Concavalin A

Concanavalin A Hepatitis

Concanavalin A (Con A) is a plant lectin that’s purified from jack beans. Con A binds to the mannose residues of assorted glycoproteins and prompts lymphocytes. When Con A is run to mice, liver damage that will depend on the activation of T lymphocytes by macrophages happens (Tiegs et al., 1992). Due to this fact, the mannequin may enable the examine of the pathophysiology of immunologically mediated hepatic issues, resembling AIH. TNF-α and IFN-γ play vital roles in Con A–induced liver damage (Gantner et al., 1995; Kusters et al., 1996) and IL-10 prevents liver damage on this mannequin (Di Marco et al., 1999; Louis et al., 1997). Blood ranges of IL-2, IL-4, and IFN-γ dramatically enhance after administration of Con A (Wang et al., 2012). Main drawbacks of this mannequin embrace the dearth of circulating autoantibodies and fast hepatocyte injury following a single-dose Con A injection, which isn’t a typical characteristic of persistent AIH.

 

Lectins as modulators of autophagy in most cancers immunotherapy

Concanavalin A prompts T cells and pure killer cells and triggers anticancer immune responses

Since ConA is a well known T cell mitogen it might additionally set off anticancer immune responses by activating tumor particular CTLs. Certainly, therapy of hepatoma-bearing mice (ML-14a cells) with ConA (7.5 mg/kg) strongly diminished liver tumor formation and extended survival, whereby 40% of the animals had been tumor free on the finish of the experiment [8]. Lymphocytic infiltrates round tumor nodules had been noticed in ConA-treated animals, suggesting T cell mediated responses. Certainly, the depletion of CD8+ T cells utterly abrogated the therapeutic results of ConA, whereas the depletion of CD4+ T cells solely partly prevented ConA-mediated inhibition of tumor formation (Fig. 4A). Consistent with this examine, ConA triggered CD4+ and CD8+ T cell activation in mice as proven by the upregulated expression of CD69 [74].

Concavalin A
Concanavalin A

As well as, ConA-treated mice contained elevated numbers of activated pure killer (NK) cells, T cells, and NK T cells, which confirmed robust cytotoxic exercise in opposition to murine lymphoma cells in ex vivo assays. That is additionally translated right into a strongly diminished variety of liver nodules upon ConA therapy of colon cancer-bearing mice (colon-26), an have an effect on that was abrogated upon NK cell depletion (Fig. 4A). Of observe, NK cells in immunodeficient nude mice (missing NKT and T cells) weren’t activated upon ConA therapy, suggesting a job of the adaptive immune system in activating NK cells [74].

 

Moreover, all results had been abrogated in IFNγ knock-out mice, displaying the significance of an lively immune response. Nevertheless, the therapy with ConA of hepatoma-bearing SCID mice additionally considerably inhibited liver tumor formation, however solely on the highest dose of 20 mg/kg [8]. As SCID mice lack purposeful lymphocytes, these information counsel a direct cytotoxic impact of ConA towards the most cancers cells. Certainly, ConA induced direct autophagy-dependent cell demise in these mice (see above paragraph about ConA and most cancers cell demise). Thus, ConA prompts CD8+ CTLs and NK cells that cut back in vivo tumor progress and potentiate ex vivo tumor cell lysis (Fig. 4A).

 

Programmed Cell Death Protein 10 (PDCD10) Antibody

20-abx214660
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Programmed Cell Death Protein 10 (PDCD10) Antibody (HRP)

20-abx310611
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Programmed Cell Death Protein 10 (PDCD10) Antibody (FITC)

20-abx310612
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Programmed Cell Death Protein 10 (PDCD10) Antibody (Biotin)

20-abx310613
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human Programmed Cell Death Protein 10 (PDCD10) ELISA Kit

abx382112-96tests 96 tests
EUR 911

Chicken Programmed cell death protein 10, PDCD10 ELISA KIT

ELI-35614c 96 Tests
EUR 928

Human Programmed cell death protein 10, PDCD10 ELISA KIT

ELI-20923h 96 Tests
EUR 824

Mouse Programmed cell death protein 10, Pdcd10 ELISA KIT

ELI-14591m 96 Tests
EUR 865

Programmed Cell Death 5 Protein

20-abx262104
  • EUR 4490.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug

Programmed Cell Death 6 Protein

20-abx262735
  • EUR 328.00
  • EUR 6397.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg

Programmed Cell Death 4 Protein

20-abx262858
  • EUR 328.00
  • EUR 6397.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg

Recombinant Programmed Cell Death Protein 6 (PDCD6)

4-RPL096Hu01
  • EUR 494.24
  • EUR 235.00
  • EUR 1578.40
  • EUR 592.80
  • EUR 1085.60
  • EUR 394.00
  • EUR 3796.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Programmed Cell Death Protein 6 expressed in: E.coli

Recombinant Programmed Cell Death Protein 5 (PDCD5)

4-RPL105Hu01
  • EUR 483.49
  • EUR 232.00
  • EUR 1538.08
  • EUR 579.36
  • EUR 1058.72
  • EUR 386.00
  • EUR 3695.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Programmed Cell Death Protein 5 expressed in: E.coli

Recombinant Programmed Cell Death Protein 1 (PDCD1)

4-RPA751Hu01
  • EUR 510.37
  • EUR 239.00
  • EUR 1638.88
  • EUR 612.96
  • EUR 1125.92
  • EUR 404.00
  • EUR 3947.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Programmed Cell Death Protein 1 expressed in: E.coli

Recombinant Programmed Cell Death Protein 1 (PDCD1)

4-RPA751Ra01
  • EUR 503.20
  • EUR 238.00
  • EUR 1612.00
  • EUR 604.00
  • EUR 1108.00
  • EUR 400.00
  • EUR 3880.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Programmed Cell Death Protein 1 expressed in: E.coli

Recombinant Human Programmed Cell Death 5

7-05830 5µg Ask for price

Recombinant Human Programmed Cell Death 5

7-05831 20µg Ask for price

Recombinant Human Programmed Cell Death 5

7-05832 1mg Ask for price

Recombinant Human Programmed Cell Death 6

7-05833 2µg Ask for price

Recombinant Human Programmed Cell Death 6

7-05834 10µg Ask for price

Recombinant Human Programmed Cell Death 6

7-05835 1mg Ask for price

Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-100ug

QP8043-ec-100ug 100ug
EUR 408

Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-10ug

QP8043-ec-10ug 10ug
EUR 200

Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-1mg

QP8043-ec-1mg 1mg
EUR 1632

Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-200ug

QP8043-ec-200ug 200ug
EUR 634

Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-500ug

QP8043-ec-500ug 500ug
EUR 1060

Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-50ug

QP8043-ec-50ug 50ug
EUR 263