immpact-international

Multiple myeloma with t(11;14)-associated immature phenotype has lower CD38 expression and higher BCL2 dependence

CD38 expression on myeloma cells is a important issue affecting the early response to the anti-CD38 antibody daratumumab. Nevertheless, elements affecting CD38 expression in untreated a number of myeloma are usually not totally elucidated. On this research, we discovered that CD38 expression was considerably decrease in myeloma sufferers with the translocation t(11;14)-associated immature plasma cell phenotype, and significantly in these expressing B-cell-associated genes comparable to PAX5 and CD79A. CD138, a consultant marker of plasmacytic differentiation, was additionally considerably decrease in these sufferers, suggesting that CD38 expression could also be related to the differentiation and maturation phases of myeloma cells.
Moreover, the BCL2/BCL2L1 ratio, a response marker of the BCL2 inhibitor venetoclax, was considerably larger in sufferers with the immature phenotype expressing B-cell-associated genes. The BCL2/BCL2L1 ratio and CD38 expression had been considerably negatively correlated. We additionally confirmed that sufferers with translocation t(11;14) expressing B-cell-associated genes had been certainly much less delicate to daratumumab-mediated direct cytotoxicity however extremely delicate to venetoclax therapy in ex vivo assays. Furthermore, all-trans-retinoic acid, which boosts CD38 expression and induces cell differentiation in myeloma cells, diminished B-cell marker expression and the BCL2/BCL2L1 ratio in myeloma cell traces, resulting in diminished efficacy of venetoclax.
Venetoclax particularly induces cell dying in myeloma with t(11;14), though why sufferers with translocation t(11;14) present BCL2 dependence is unclear. These outcomes counsel that BCL2 dependence, in addition to CD38 expression, are deeply related to the differentiation and maturation phases of myeloma cells. This research highlights the significance of analyzing t(11;14) and contemplating cell maturity in myeloma therapy methods.
Key phrases: BCL2; CD38; daratumumab; a number of myeloma; venetoclax.

CD142 performs a key position within the carcinogenesis of gastric adenocarcinoma by inhibiting BCL2-dependent autophagy

CD142 is expressed on the floor of a number of malignant tumors and contributes to varied carcinogenesis. Nevertheless, the position of CD142 within the pathogenesis of GAC stays unclear. This research aimed to analyze the position of CD142 in GAC carcinogenesis. Our outcomes confirmed that CD142 expression was considerably elevated in GAC most cancers tissues, particularly in these with vital invasion or metastasis. The invasion and migration of CD142-positive SNU16 cells had been considerably elevated in contrast with these of CD142-negative cells. Furthermore, CD142 overexpression promoted the invasion and migration of SGC083 cells, however CD142 silencing was opposite. As well as, there was a constructive correlation between CD142 expression of most cancers tissues and serum IL-Eight ranges. CD142 overexpression promotes IL-Eight manufacturing in SGC083 cells.
In vivo evaluation confirmed that the implantation of CD142-positive SNU16 cells promoted the expansion of xenograft tumor and the manufacturing of IL-8. Mechanistically, CD142 silencing not solely inhibited the expression of BCL2 and the interplay between BCL2 and Beclin1, but additionally promoted the autophagic response in SGC083. Moreover, CD142 silencing-induced IL-Eight degradation was recovered by therapy of autophagy inhibitor 3-MA. CD142 can inhibit autophagic cell dying and the autophagic degradation of IL-Eight in GAC, which exerts an efficient impact on GAC carcinogenesis.
immpact-international
immpact-international

The Incidence and Remedy Response of Double Expression of MYC and BCL2 in Sufferers with Diffuse Giant B-Cell Lymphoma: A Systematic Evaluate and Meta-Evaluation

MYC/BCL2 protein co-expression (i.e., double expressor) has been proven to be a unfavorable predictor of consequence in diffuse massive B-cell lymphoma (DLBCL). We aimed to determine the incidence of double expressor standing in sufferers with de novo DLBCL and determine the predictive worth of this biomarker on therapy response by way of systematic evaluate and meta-analysis. PubMed and Embase had been looked for research printed by way of December 2019 that reported proportions of double expressor DLBCL. The pooled proportions of MYC and BCL2 expression, each alone and together, had been computed utilizing the inverse variance technique for calculating weights and by the DerSimonian-Laird technique. The pooled odds ratios (ORs) of full remission (CR) fee had been calculated, and meta-regression evaluation was carried out to discover heterogeneity. Forty-one research (7054 sufferers) had been included.
The pooled incidence of double expressor standing in DLBCL was 23% (95% confidence interval [CI], 20-26%), with an adjusted estimate of 31% (95% CI, 27-36%). Neither MYC/BCL2 protein cutoff values, race, imply, or median age of included sufferers, or total research high quality was a big issue of heterogeneity (p ≥ 0.20). Instances with out double expressor standing demonstrated the next likelihood of CR to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone therapy (OR, 2.69; 95% CI, 1.55-4.67). Our outcomes reaffirm the predictive energy of this essential biomarker.
Key phrases: immunohistochemistry; lymphoma; meta-analysis; systematic evaluate.

Computational research on novel pure inhibitors focusing on BCL2

 

Very best lead compounds and candidate medication with inhibitory impact on BCL2 had been screened from ZINC database, which laid a basis for drug growth and compound enchancment of drug therapy for diffuse massive B-cell lymphoma (DLCBL). Identification of potential BCL2 inhibitors by computer-aided digital screening. Libdock was utilized to 17,931 compounds and the highest 20 had been chosen for additional evaluation. Chosen compounds had been carried out absorption, distribution, metabolism, and excretion (ADME) and toxicity prediction. The binding affinity between the chosen ligands and BCL2 was confirmed by Molecular docking.

 

  • The brand new pure compounds, ZINC00000255131 and ZINC00013298233, had been discovered to bind intently with BCL2. Moreover, all of them scored decrease in ames-induced mutagenicity, rodent carcinogenicity, non-developmental toxicity potential, and cytochrome P4502D6 tolerance. Molecular dynamics simulation reveals that the mixtures of ZINC00000255131 and ZINC00013298233 with BCL2 within the pure surroundings are extra secure.
  • Two new compounds, ZINC00000255131 and ZINC00013298233, had been discovered to be potential inhibitors of BCL2. These compounds have been proved to be secure, which is of nice significance for the event and enchancment of DLCBL medication.

 

Assembling BH3-mimic peptide right into a nanocluster to focus on intracellular Bcl2 in the direction of the apoptosis induction of most cancers cell

Bcl-2, an anti-apoptotic protein, is at all times overexpressed in tumor cells to suppress the pro-apoptotic perform of Bax, thereby prolonging the lifetime of tumor. Nevertheless, BH3 proteins may instantly activate Bax by way of antagonizing Bcl-2 to induce apoptosis in response to the stimulation. Thus, mimicking BH3 proteins with a peptide is a possible technique for anti-cancer remedy. Sadly, medical translation of BH3-mimic peptide is hindered by its inefficacious mobile internalization and proteolysis resistance.
Herein, we translated a BH3-mimic peptide right into a peptide-auric spheroidal nanocluster (BH3-AuNp), during which polymeric BH3-Auric precursors [Au1+-S-BH3]n are in-situ self-assembled on the floor of gold nanoparticles by a one-pot synthesis. Expectedly, this technique may enhance the anti-proteolytic potential and cytomembrane penetrability of the BH3 peptide.
Consequently, BH3-AuNp efficiently induced the apoptosis of two most cancers cell traces by an order of magnitude in comparison with BH3. This therapeutic and possible peptide nano-engineering technique will assist peptides overcome the pharmaceutical obstacles, awaken its organic capabilities, and probably revive the analysis about peptide-derived nanomedicine.
Recombinant Human Hydroxymethylglutaryl-CoA lyase, GST, E.coli-10ug
QP6168-ec-10ug 10ug
EUR 200
Recombinant Human Hydroxymethylglutaryl-CoA lyase, GST, E.coli-1mg
QP6168-ec-1mg 1mg
EUR 1632
Recombinant Human Hydroxymethylglutaryl-CoA lyase, GST, E.coli-200ug
QP6168-ec-200ug 200ug
EUR 634
Recombinant Human Hydroxymethylglutaryl-CoA lyase, GST, E.coli-500ug
QP6168-ec-500ug 500ug
EUR 1060
Recombinant Human Hydroxymethylglutaryl-CoA lyase, GST, E.coli-50ug
QP6168-ec-50ug 50ug
EUR 263
2-hydroxyacyl-CoA lyase 1 Antibody
39416-100ul 100ul
EUR 390
Human Hydroxymethylglutaryl-CoA lyase, mitochondrial (HMGCL)
1-CSB-EP010563HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 58.5 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Hydroxymethylglutaryl-CoA lyase, mitochondrial(HMGCL) expressed in E.coli
Hydroxymethylglutaryl-CoA Lyase, Mitochondrial (HMGCL) Antibody
20-abx007133
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.
Hydroxymethylglutaryl-CoA Lyase, Mitochondrial (HMGCL) Antibody
20-abx002856
  • EUR 411.00
  • EUR 592.00
  • 100 ul
  • 200 ul
  • Shipped within 5-10 working days.
Hydroxymethylglutaryl-CoA Lyase, Mitochondrial (HMGCL) Antibody
abx037986-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.
Hydroxymethylglutaryl-CoA Lyase, Mitochondrial (HMGCL) Antibody
20-abx142080
  • EUR 370.00
  • EUR 606.00
  • EUR 300.00
  • 100 ul
  • 200 ul
  • 50 ul
  • Shipped within 5-10 working days.
Hydroxymethylglutaryl-CoA Lyase, Mitochondrial (HMGCL) Antibody
abx030051-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.
Hydroxymethylglutaryl-CoA Lyase, Mitochondrial (HMGCL) Antibody
abx030051-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.
Hydroxymethylglutaryl-CoA Lyase, Mitochondrial (HMGCL) Antibody
abx028671-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.
Hydroxymethylglutaryl-CoA Lyase, Mitochondrial (HMGCL) Antibody
abx028671-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.
Hydroxymethylglutaryl-CoA Lyase, Mitochondrial (HMGCL) Antibody
abx233928-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.
Hydroxymethylglutaryl-CoA Lyase, Mitochondrial (HMGCL) Antibody
20-abx322761
  • EUR 439.00
  • EUR 328.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.
anti-2 Hydroxy phytanoyl CoA lyase
YF-PA18196 50 ul
EUR 363
Description: Mouse polyclonal to 2 Hydroxy phytanoyl CoA lyase
anti-2 Hydroxy phytanoyl CoA lyase
YF-PA18197 50 ug
EUR 363
Description: Mouse polyclonal to 2 Hydroxy phytanoyl CoA lyase
Rhodobacter sphaeroides Modification methylase RsrI (rsrIM)
1-CSB-EP318583RLE
  • EUR 611.00
  • EUR 309.00
  • EUR 1827.00
  • EUR 939.00
  • EUR 1218.00
  • EUR 397.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 51.7 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Rhodobacter sphaeroides Modification methylase RsrI(rsrIM) expressed in E.coli
HMGCL 3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase Human Recombinant Protein
PROTP35914 Regular: 20ug
EUR 317
Description: HMGCL Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 323 amino acids (28-325) and having a molecular mass of 34.2kDa.;HMGCL is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
2-Hydroxyacyl-CoA Lyase 1 (HACL1) Antibody
20-abx214192
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.
2-Hydroxyacyl-CoA Lyase 1 (HACL1) Antibody
20-abx214272
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.
2-Hydroxyacyl-CoA Lyase 1 (HACL1) Antibody
20-abx110706
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.
2-Hydroxyacyl-CoA Lyase 1 (HACL1) Antibody
abx038305-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.
2-Hydroxyacyl-CoA Lyase 1 (HACL1) Antibody
abx145222-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.
Chicken Hydroxymethylglutaryl- CoA lyase, HMGCL ELISA KIT
ELI-27799c 96 Tests
EUR 928
2-Hydroxyacyl-CoA Lyase 1 (HACL1) Antibody
abx233746-100ug 100 ug
EUR 509
  • Shipped within 5-12 working days.
Argininosuccinate Lyase (Recombinant)
20-abx073248
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.
Hmgcl ELISA Kit| Rat Hydroxymethylglutaryl-CoA lyase, mitochond
EF018825 96 Tests
EUR 689
Hmgcl ELISA Kit| Mouse Hydroxymethylglutaryl-CoA lyase, mitocho
EF015212 96 Tests
EUR 689
Human Hydroxymethylglutaryl-CoA Lyase, Mitochondrial (HMGCL) ELISA Kit
abx387826-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.
HMGCL Human, 3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase Human Recombinant Protein, Sf9
PROTP35914-1 Regular: 10ug
EUR 317
Description: HMGCL Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 305 amino acids (28-325 a.a.) and having a molecular mass of 32.5kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa). HMGCL is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Mouse 2- hydroxyacyl- CoA lyase 1, Hacl1 ELISA KIT
ELI-27598m 96 Tests
EUR 865
Human 2- hydroxyacyl- CoA lyase 1, HACL1 ELISA KIT
ELI-27733h 96 Tests
EUR 824
Human 2-Hydroxyacyl-CoA Lyase 1 (HACL1) ELISA Kit
abx387730-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.
Recombinant human Selenocysteine lyase
P2183 100ug Ask for price
  • Uniprot ID: Q96I15
  • Reconstitution: Metal affinity chromatography on Fn Super Capacity Column (Nickel)
Description: Recombinant protein for human Selenocysteine lyase
Cystathionine gamma-lyase, Recombinant
NATE-1144 5mg
EUR 594
Cystathionine β-lyase, Recombinant
NATE-1146 100mg
EUR 594
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase Like 1 (HMGCLL1) Antibody
abx038037-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.
Rat 3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL) ELISA Kit
abx391467-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase Like 1 (HMGCLL1) Antibody
20-abx310139
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Mouse 3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL) ELISA Kit
abx389578-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.
Recombinant E.Coli N-Acetylneuraminate Lyase
7-03193 5µg Ask for price
Recombinant E.Coli N-Acetylneuraminate Lyase
7-03194 20µg Ask for price
Recombinant E.Coli N-Acetylneuraminate Lyase
7-03195 1mg Ask for price
N-acetylneuraminate Pyruvate Lyase (Recombinant)
20-abx073214
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.
E.Coli N-Acetylneuraminate Lyase (Recombinant)
20-abx073216
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.
E.coli Deoxyribodipyrimidine photo-lyase (Recombinant)
20-abx073964
  • EUR 1609.00
  • EUR 328.00
  • EUR 230.00
  • 100 ug
  • 10 ug
  • 2 µg
  • Shipped within 5-10 working days.
Recombinant human Cystathionine gamma-lyase
P1802 100ug Ask for price
  • Uniprot ID: P32929
  • Reconstitution: Metal affinity chromatography on Fn Super Capacity Column (Nickel)
Description: Recombinant protein for human Cystathionine gamma-lyase
Homocysteine ?,?-Lyase (rHCYase), Active, Recombinant
P1117-200
EUR 425
Recombinant Cystathionine Gamma Lyase (CSE)
4-RPB538Hu01
  • EUR 521.12
  • EUR 242.00
  • EUR 1679.20
  • EUR 626.40
  • EUR 1152.80
  • EUR 412.00
  • EUR 4048.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P32929
  • Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 28.1kDa
  • Isoelectric Point: 7.3
Description: Recombinant Human Cystathionine Gamma Lyase expressed in: E.coli
Recombinant Cystathionine Gamma Lyase (CSE)
4-RPB538Mu01
  • EUR 528.29
  • EUR 244.00
  • EUR 1706.08
  • EUR 635.36
  • EUR 1170.72
  • EUR 416.00
  • EUR 4115.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q8VCN5
  • Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 26.7kDa
  • Isoelectric Point: 8.2
Description: Recombinant Mouse Cystathionine Gamma Lyase expressed in: E.coli
Recombinant Cystathionine Gamma Lyase (CSE)
4-RPB538Ra01
  • EUR 530.08
  • EUR 245.00
  • EUR 1712.80
  • EUR 637.60
  • EUR 1175.20
  • EUR 418.00
  • EUR 4132.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P18757
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 59.1kDa
  • Isoelectric Point: Inquire
Description: Recombinant Rat Cystathionine Gamma Lyase expressed in: E.coli
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase Like 1 (HMGCLL1) Antibody (HRP)
20-abx310140
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase Like 1 (HMGCLL1) Antibody (FITC)
20-abx310141
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase Like 1 (HMGCLL1) Antibody (Biotin)
20-abx310142
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Acyl-CoA oxidase, Recombinant
DIA-292 1ku
EUR 270
Methylmalonyl CoA Epimerase (Recombinant)
20-abx073165
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.
Acyl-CoA synthetase, recombinant
NATE-1682 1ku
EUR 594
Human 3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase Like 1 (HMGCLL1) ELISA Kit
abx384525-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.
Mouse 3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase Like 1 (HMGCLL1) ELISA Kit
abx388460-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.
Recombinant Human N-acetylneuraminate Pyruvate Lyase
7-03232 5µg Ask for price
Recombinant Human N-acetylneuraminate Pyruvate Lyase
7-03233 20µg Ask for price
Recombinant Human N-acetylneuraminate Pyruvate Lyase
7-03234 1mg Ask for price
L-Methionine ?-Lyase, Pseudomonas putida recombinant
7848-100
EUR 158
L-Methionine ?-Lyase, Pseudomonas putida recombinant
7848-500
EUR 387
Recombinant Human Cystathionine γ-Lyase/CTH
CF60-10ug 10ug
EUR 146
Description: Supplied as a 0.2 μm filtered solution of 20mM PB,150mM NaCl,20% Glycerol,pH7.4.
Recombinant Human Cystathionine γ-Lyase/CTH
CF60-1mg 1mg
EUR 2283
Description: Supplied as a 0.2 μm filtered solution of 20mM PB,150mM NaCl,20% Glycerol,pH7.4.
Recombinant Human Cystathionine γ-Lyase/CTH
CF60-500ug 500ug
EUR 1613
Description: Supplied as a 0.2 μm filtered solution of 20mM PB,150mM NaCl,20% Glycerol,pH7.4.
Recombinant Human Cystathionine γ-Lyase/CTH
CF60-50ug 50ug
EUR 339
Description: Supplied as a 0.2 μm filtered solution of 20mM PB,150mM NaCl,20% Glycerol,pH7.4.
ATP citrate lyase recombinant monoclonal antibody
A5181 100ul X 3
EUR 595
  • Comparisons between Mnoclonal, Polyclonal and Recombinant antibodies and their benefits: Regular monoclonal antibodies have higher purity, better specificity and less lot-to-lot variations than polyclonal antibodies. Recombinant antibodies, however,
  • Show more
Description: A recombinant monoclonal antibody from rabbit against human ATP citrate lyase for WB,ELISA
Hyaluronate Lyase from Streptococcus pyogenes, recombinant
NATE-0346 10mg
EUR 367
ASL Argininosuccinate Lyase Human Recombinant Protein
PROTP04424 Regular: 20ug
EUR 317
Description: ASL Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 484 amino acids (1-464) and having a molecular mass of 53.8kDa.;ASL is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
ADSL Adenylosuccinate Lyase Human Recombinant Protein
PROTP30566 Regular: 20ug
EUR 317
Description: ADSL Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 520 amino acids (1-484) and having a molecular mass of 59kDa.;ADSL is fused to a 36 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Recombinant Human Acetyl-COA Acyltransferase
7-02362 5µg Ask for price
Recombinant Human Acetyl-COA Acyltransferase
7-02363 20µg Ask for price
Recombinant Human Acetyl-COA Acyltransferase
7-02364 1mg Ask for price
Recombinant Human Methylmalonyl CoA Epimerase
7-02737 5µg Ask for price
Recombinant Human Methylmalonyl CoA Epimerase
7-02738 20µg Ask for price
Recombinant Human Methylmalonyl CoA Epimerase
7-02739 1mg Ask for price
Acyl-CoA Thioesterase 8 (Recombinant)
20-abx073398
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.
Acyl-CoA Thioesterase 11 (Recombinant)
20-abx073416
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.
3-Hydroxyisobutyryl-CoA Hydrolase (Recombinant)
20-abx073796
  • EUR 328.00
  • EUR 6397.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.
Recombinant human Acyl-CoA desaturase
P1988 100ug Ask for price
  • Uniprot ID: O00767
  • Reconstitution: Metal affinity chromatography on Fn Super Capacity Column (Nickel)
Description: Recombinant protein for human Acyl-CoA desaturase
Recombinant Human Selenocysteine Lyase/SCLY (N-6His)
CE52-10ug 10ug
EUR 202
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.
Recombinant Human Selenocysteine Lyase/SCLY (N-6His)
CE52-1mg 1mg
EUR 2283
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.

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