IMMPACT:Initiative for Cell Mortality Programme Assessment.

Cell Death, Apoptosis, Oxidative stress, Caspase, BCL2

immpact-international

Outcomes of patients with CLL sequentially resistant to both BCL2 and BTK inhibition

Covalent Bruton tyrosine kinase inhibitors (BTKis) and the BCL2 inhibitor venetoclax have significantly improved outcomes for patients with chronic lymphocytic leukemia (CLL), especially those with biologically adverse disease. Patients with CLL resistant to their first targeted agent (TA) can be effectively treated with the alternative class. However, relapses are expected with second-line TA therapy, and the clinical challenge of double class-resistant disease is now emerging with increasing frequency. To define the characteristics and outcomes of patients with double class-resistant disease, we retrospectively analyzed 17 patients who developed progressive disease (PD) on both TA classes for CLL (venetoclax, then BTKi, n=12; BTKi, then venetoclax, n=5). The cohort was heavily pre-treated (median lines of prior therapy: 4) and enriched for adverse disease genetics (complex karyotype: 12/12 tested, 100%; del(17p)/TP53 mutations: 15/17, 88%). The median time to progression on prior venetoclax was 24 (range 6-94) months, and on prior BTKi was 25 (range 1-55) months. Progression on second-line TA was manifest as progressive CLL in 11 patients and as Richter transformation in six. The median overall survival after progression on second-line TA was 3.6 (95%CI 2-11) months. Patients with double class-resistant CLL have a dismal prognosis, representing a group of high unmet need.

Concerted hepatoprotective effect of bradykinin potentiating factor and low dose of γ- radiation on Naja haje envenomed rats via Bax/Bcl2 pathway

 

This study investigates the concerted hepatoprotective effects for three doses of bradykinin potentiating factor (BPF) and/or followed by exposure to a low dose of γ-radiation (LDR) against Naja haje envenoming in rats. Male rats were injected with three consecutive doses of BPF (1μg/g i.p. for 3 days), followed by exposure to a low dose of gamma radiation (0.5 Gy), and then rats were injected with a dose of Naja haje venom (250 μg/kg i.p.).
  • Results showed that Naja haje causes liver damage, significant elevation of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), cytochrome c, Nitric oxide (NO), malondialdehyde (MDA) and significant depletion in glutathione peroxidase (GPx) contents. In addition, significant depletion in B-cell lymphoma 2 (Bcl-2) and significant elevation in BcL-2 associated X (Bax protein), nuclear factor kappa B (NF-κB), interleukin-1β (IL-1β) in hepatocytes.
  • Bradykinin potentiating factor and/or low dose of γ-radiation caused improvement in liver damage caused by Naja haje venom by a significant decrease in ALT, AST, ALP levels, Bax, cytochrome c, NF-κB, IL-1β, NO and MDA contents, BPF alone or combined with low dose radiation caused a significant increase in Bcl2 and GPx contents.In conclusion, the concerted impact of BPF and LDR may provide an effective venom detoxification tool that helps to reduce hepatic toxicity and extends the lifespan.

 

MYC, BCL2, and BCL6 expression as prognostic indicators in primary central nervous system lymphoma: A systematic review and meta-analysis

Background: We conducted a meta-analysis to comprehensively assess the predictive role of MYC, BCL2, and BCL6 genetic alterations and protein expression in PCNSL for clinical application.
Methods: A systematic retrieval was performed on PubMed, Embase, the Cochrane library, Web of Science, Scopus, and 2 Chinese databases. Cohort studies discussing the prognostic impact of MYC, BCl2, or BCL6 genetic alterations or gene expression in PCNSL were selected. The pooled hazard ratio (HR) and median survival ratio (MSR) were calculated.
Results: 31 studies involving 1739 patients fulfilled our inclusion criteria. MYC expression was significantly associated with short median OS (MSR = 0.62; 95%CI, 0.44-0.88) and PFS (HR = 1.53; 95%CI, 1.06-2.20). No significant association was found between BCL2 expression and OS or PFS (P > 0.05). BCL6 protein positivity was significantly associated with extended median OS (MSR = 1.62; 95%CI, 1.10-2.40).
MYC and BCL2 coexpression was significantly associated with short median OS (MSR = 0.61; 95%CI, 0.45-0.84). Subgroup analysis demonstrated that MYC protein positivity remained as a significant indicator for short median OS in studies whose sample size ≥ 45, treatment without WBRT, quality scale score ≥ 7, and positivity threshold set at 40% stratum (MSR < 1 and P < 0.05), but failed to reach a statistically significant difference in the other stratum.
Conclusions: MYC expression predicts inferior median OS and PFS in PCNSL. BCL6 protein positivity is associated with a favorable prognosis. The sample size, average age of subjects, WBRT treatment, study quality, and cut-off values for discriminating positive and negative protein expression in IHC may be origins of heterogeneity.
Keywords: BCL2; BCL6; Gene expression; MYC; Primary central nervous system lymphoma.
immpact-international
immpact-international

Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss

Melanomas driven by loss of the NF1 tumor suppressor have a high risk of treatment failure and effective therapies have not been developed. Here we show that loss-of-function mutations of nf1 and pten result in aggressive melanomas in zebrafish, representing the first animal model of NF1-mutant melanomas harboring PTEN loss. MEK or PI3K inhibitors show little activity when given alone due to cross-talk between the pathways, and high toxicity when given together.
The mTOR inhibitors, sirolimus, everolimus, and temsirolimus, were the most active single agents tested, potently induced tumor-suppressive autophagy, but not apoptosis. Because addition of the BCL2 inhibitor venetoclax resulted in compensatory upregulation of MCL1, we established a three-drug combination composed of sirolimus, venetoclax, and the MCL1 inhibitor S63845. This well-tolerated drug combination potently and synergistically induces apoptosis in both zebrafish and human NF1/PTEN-deficient melanoma cells, providing preclinical evidence justifying an early-stage clinical trial in patients with NF1/PTEN-deficient melanoma.

BCL2 inhibitors and MCL1 inhibitors for hematological malignancies

BCL2 and MCL1 are commonly expressed pro-survival (anti-apoptotic) proteins in hematological cancers and play important roles in their biology either through dysregulation or by virtue of intrinsic importance to the cell-of-origin of the malignancy. A new class of small molecule anti-cancer drugs, BH3-mimetics, now enable specific targeting of these proteins in patients.
BH3-mimetics act by inhibiting the pro-survival BCL2 proteins to enable the activation of BAX and BAK, apoptosis effectors which permeabilize the outer mitochondrial membrane, triggering apoptosis directly in many cells and sensitizing others to cell death when combined with other anti-neoplastic drugs. Venetoclax, a specific inhibitor of BCL2, is the first approved in class, demonstrating striking single agent activity in chronic lymphocytic leukemia (CLL) and in other lymphoid neoplasms, as well as activity against acute myeloid leukemia (AML), especially when used in combination.
Key insights from the venetoclax experience include that responses occur rapidly, with major activity as monotherapy proving to be the best indicator for success in combination regimens. This emphasizes the importance of adequate single agent studies for drugs in this class. Furthermore, secondary resistance is common with long-term exposure and often mediated by genetic or adaptive changes in the apoptotic pathway, suggesting that BH3-mimetics are better suited to limited-duration, rather than continuous, therapy. The success of venetoclax has inspired development of BH3-mimetics targeting MCL1. Despite promising preclinical activity against MYC-driven lymphomas, myeloma and AML, their success may particularly depend on their tolerability profile given physiological roles for MCL1 in several non-hematological tissues.

Human Polyadenylate- binding protein 2, PABPN1 ELISA KIT
ELI-21970h 96 Tests
EUR 988.8

Human Polyadenylate- binding protein 3, PABPC3 ELISA KIT
ELI-43230h 96 Tests
EUR 988.8

Human Polyadenylate- binding protein 4, PABPC4 ELISA KIT
ELI-35673h 96 Tests
EUR 988.8

Mouse Polyadenylate- binding protein 1, Pabpc1 ELISA KIT
ELI-21806m 96 Tests
EUR 1038

Human Polyadenylate- binding protein 5, PABPC5 ELISA KIT
ELI-21807h 96 Tests
EUR 988.8

Human Polyadenylate- binding protein 1, PABPC1 ELISA KIT
ELI-12384h 96 Tests
EUR 988.8

Recombinant Human Polyadenylate-Binding Protein-Interacting Protein 2
7-05797 5µg Ask for price

Recombinant Human Polyadenylate-Binding Protein-Interacting Protein 2
7-05798 25µg Ask for price

Recombinant Human Polyadenylate-Binding Protein-Interacting Protein 2
7-05799 1mg Ask for price

Human Polyadenylate- binding protein 4- like, PABPC4L ELISA KIT
ELI-21969h 96 Tests
EUR 988.8

Human Polyadenylate- binding protein 1- like, PABPC1L ELISA KIT
ELI-14688h 96 Tests
EUR 988.8

PAIP2 Polyadenylate-Binding Protein-Interacting protein 2 Human Recombinant Protein
PROTQ9BPZ3 Regular: 25ug
EUR 380.4
Description: Recombinant Human PAIP2 produced in E.Coli is a single,non-glycosylated polypeptide chain containing 147 amino acids (1-127 a.a.) and having a molecular mass of 17.1 kDa.;PAIP2 human recombinant is fused to 20 amino acid His Tag at N-terminus and purified by convential chromatogrpahy techniques.

Recombinant Human Polyadenylate-binding protein 1, His-SUMO, E.coli-1mg
QP6461-ec-1mg 1mg
EUR 1958.4

Recombinant Human Polyadenylate-binding protein 1, His-SUMO, E.coli-100ug
QP6461-ec-100ug 100ug
EUR 489.6

Recombinant Human Polyadenylate-binding protein 1, His-SUMO, E.coli-10ug
QP6461-ec-10ug 10ug
EUR 240

Recombinant Human Polyadenylate-binding protein 1, His-SUMO, E.coli-200ug
QP6461-ec-200ug 200ug
EUR 760.8

Recombinant Human Polyadenylate-binding protein 1, His-SUMO, E.coli-500ug
QP6461-ec-500ug 500ug
EUR 1272

Recombinant Human Polyadenylate-binding protein 1, His-SUMO, E.coli-50ug
QP6461-ec-50ug 50ug
EUR 315.6

Recombinant Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1)
4-RPC396Hu01
  • EUR 464.06
  • EUR 247.20
  • EUR 1410.24
  • EUR 550.08
  • EUR 980.16
  • EUR 386.40
  • EUR 3345.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Cytoplasmic Polyadenylation Element Binding Protein 1 expressed in: E.coli

CPEB1 Cytoplasmic Polyadenylation Element Binding Protein 1 Human Recombinant Protein
PROTQ9BZB8 Regular: 20ug
EUR 380.4
Description: CPEB1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 584 amino acids (1-561) and having a molecular mass of 64.5 kDa.;CPEB1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Polyadenylate-Binding Protein 2 (PABPN1) Antibody
20-abx217614
  • EUR 510.00
  • EUR 410.40
  • 100 ug
  • 50 ug

Polyadenylate-Binding Protein 2 (PABPN1) Antibody
20-abx004649
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Polyadenylate-Binding Protein 2 (PABPN1) Antibody
abx029099-400ul 400 ul
EUR 627.6

Polyadenylate-Binding Protein 2 (PABPN1) Antibody
abx029099-80l 80 µl
EUR 343.2

Polyadenylate-Binding Protein-Interacting Protein 2 Protein
20-abx260556
  • EUR 3433.20
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

Human Polyadenylate-binding protein 1 (PABPC1)
1-CSB-EP017352HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Polyadenylate-binding protein 1(PABPC1),partial expressed in E.coli

Polyadenylate-Binding Protein-Interacting Protein 2 Antibody
20-abx137383
  • EUR 844.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 20 ug
  • 5 ug

Embryonic polyadenylate-binding protein 2 Antibody / PABPN1L
F54625-0.08ML 0.08 ml
EUR 140.25
Description: Binds the poly(A) tail of mRNA. (UniProt)

Embryonic polyadenylate-binding protein 2 Antibody / PABPN1L
F54625-0.4ML 0.4 ml
EUR 322.15
Description: Binds the poly(A) tail of mRNA. (UniProt)

PABPC3 Antibody / Polyadenylate-binding protein 3
F53970-0.05ML 0.05 ml
EUR 140.25
Description: Polyadenylate binding protein 3 binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1.

Polyadenylate-Binding Protein 1-Like 2 (PABPC1L2B) Antibody
abx030671-400ul 400 ul
EUR 627.6

Polyadenylate-Binding Protein 1-Like 2 (PABPC1L2B) Antibody
abx030671-80l 80 µl
EUR 343.2

Polyadenylate-Binding Protein 4-Like (PABPC4L) Antibody
abx028778-400ul 400 ul
EUR 627.6

Polyadenylate-Binding Protein 4-Like (PABPC4L) Antibody
abx028778-80l 80 µl
EUR 343.2

Human Polyadenylate-Binding Protein 1 (PABPC1) ELISA Kit
abx259760-96tests 96 tests
EUR 1093.2

Arabidopsis thaliana Polyadenylate-binding protein RBP47A (RBP47A)
1-CSB-EP522272DOA
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Arabidopsis thaliana Polyadenylate-binding protein RBP47A(RBP47A) expressed in E.coli

ELISA kit for Human Polyadenylate-binding protein 1-like (PABPC1L)
KTE61322-48T 48T
EUR 398.4
Description: Quantitative sandwich ELISA for measuring Human Polyadenylate-binding protein 1-like (PABPC1L) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Polyadenylate-binding protein 1-like (PABPC1L)
KTE61322-5platesof96wells 5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Human Polyadenylate-binding protein 1-like (PABPC1L) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Polyadenylate-binding protein 1-like (PABPC1L)
KTE61322-96T 96T
EUR 646.8
Description: Quantitative sandwich ELISA for measuring Human Polyadenylate-binding protein 1-like (PABPC1L) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Cytoplasmic Polyadenylation Element Binding Protein 1 Protein
20-abx261307
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Cytoplasmic Polyadenylation Element Binding Protein 2 (CPEB2) Antibody
20-abx318745
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Rat Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E02C1999-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E02C1999-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E02C1999-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E08C1999-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E08C1999-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E08C1999-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E07C1999-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E07C1999-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E07C1999-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Cytoplasmic Polyadenylation Element Binding Protein 2 (CPEB2) Antibody (HRP)
20-abx316337
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Goat Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E06C1999-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E06C1999-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E06C1999-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E01C1999-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E01C1999-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E01C1999-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E03C1999-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E03C1999-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E03C1999-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Cytoplasmic Polyadenylation Element Binding Protein 2 (CPEB2) Antibody (FITC)
20-abx316338
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Rabbit Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E04C1999-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E04C1999-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E04C1999-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E09C1999-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E09C1999-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E09C1999-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Cytoplasmic Polyadenylation Element Binding Protein 2 (CPEB2) Antibody (Biotin)
20-abx316339
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Guinea pig Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E05C1999-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E05C1999-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Cytoplasmic polyadenylation element binding protein 2(CPEB2) ELISA kit
E05C1999-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig Cytoplasmic polyadenylation element binding protein 2(CPEB2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) Protein
20-abx168943
  • EUR 661.20
  • EUR 292.80
  • EUR 1914.00
  • EUR 777.60
  • EUR 493.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Polyadenylate-binding protein 1 (PABPC1) control (non-asymmetric methylated) peptide
AB-23051-CP 100ug
EUR 196.8

Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) Antibody
abx231917-100ug 100 ug
EUR 577.2

Cytoplasmic Polyadenylation Element Binding Protein 4 (CPEB4) Antibody
abx231918-100ug 100 ug
EUR 610.8

Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) Antibody
20-abx004530
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) Antibody
20-abx111950
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Cytoplasmic Polyadenylation Element Binding Protein 3 (CPEB3) Antibody
20-abx111951
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Cytoplasmic Polyadenylation Element Binding Protein 4 (CPEB4) Antibody
20-abx124038
  • EUR 493.20
  • EUR 710.40
  • 100 ul
  • 200 ul

Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) Antibody
20-abx130866
  • EUR 510.00
  • EUR 159.60
  • EUR 1446.00
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Cytoplasmic Polyadenylation Element Binding Protein 4 (CPEB4) Antibody
20-abx302656
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) Antibody
20-abx310628
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) Antibody
abx028951-400ul 400 ul
EUR 627.6

Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) Antibody
abx028951-80l 80 µl
EUR 343.2

Cytoplasmic Polyadenylation Element Binding Protein 4 (CPEB4) Antibody
abx032572-400ul 400 ul
EUR 627.6

Cytoplasmic Polyadenylation Element Binding Protein 4 (CPEB4) Antibody
abx032572-80l 80 µl
EUR 343.2

Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) Antibody
abx432541-200ul 200 ul
EUR 460.8

Rat Cytoplasmic polyadenylation element binding protein 1(CPEB1) ELISA kit
E02C1998-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Cytoplasmic polyadenylation element binding protein 1(CPEB1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Cytoplasmic polyadenylation element binding protein 1(CPEB1) ELISA kit
E02C1998-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Cytoplasmic polyadenylation element binding protein 1(CPEB1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Cytoplasmic polyadenylation element binding protein 1(CPEB1) ELISA kit
E02C1998-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Cytoplasmic polyadenylation element binding protein 1(CPEB1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Cytoplasmic polyadenylation element binding protein 3(CPEB3) ELISA kit
E02C2000-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Cytoplasmic polyadenylation element binding protein 3(CPEB3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Cytoplasmic polyadenylation element binding protein 3(CPEB3) ELISA kit
E02C2000-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Cytoplasmic polyadenylation element binding protein 3(CPEB3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

 

 

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