Tag: biology cells and energy
High-Grade B-cell lymphomas with MYC and BCL2 translocations lack tumor-associated macrophages and PD-L1 expression: A possible noninflamed subgroup
We investigated the intratumoral supply of PD-L1 expression and the infiltration of tumor-associated macrophages (TAMs) in giant B-cell lymphomas (LBCL) with or with out MYC-translocation, in addition to doable correlations to BCL2- and BCL6-translocations and cell of origin (COO). 126 affected person samples have been studied in a cohort enriched for MYC translocated tumors with…
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Outcomes of patients with CLL sequentially resistant to both BCL2 and BTK inhibition
Covalent Bruton tyrosine kinase inhibitors (BTKis) and the BCL2 inhibitor venetoclax have significantly improved outcomes for patients with chronic lymphocytic leukemia (CLL), especially those with biologically adverse disease. Patients with CLL resistant to their first targeted agent (TA) can be effectively treated with the alternative class. However, relapses are expected with second-line TA therapy, and…
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Inhibition of caspase-3-mediated GSDME-derived pyroptosis aids in noncancerous tissue protection of squamous cell carcinoma patients during cisplatin-based chemotherapy
The unwanted effects of platinum-based chemotherapy are essential elements limiting the survival of oral squamous cell carcinoma (OSCC) sufferers. Present analysis means that pyroptosis is concerned on this course of. Nevertheless, how this mechanism can be utilized to cut back unwanted effects has not but been elucidated. On this examine, we reported that GSDME was…
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