Tag: biology cells concept 3
High-Grade B-cell lymphomas with MYC and BCL2 translocations lack tumor-associated macrophages and PD-L1 expression: A possible noninflamed subgroup
We investigated the intratumoral supply of PD-L1 expression and the infiltration of tumor-associated macrophages (TAMs) in giant B-cell lymphomas (LBCL) with or with out MYC-translocation, in addition to doable correlations to BCL2- and BCL6-translocations and cell of origin (COO). 126 affected person samples have been studied in a cohort enriched for MYC translocated tumors with…
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Outcomes of patients with CLL sequentially resistant to both BCL2 and BTK inhibition
Covalent Bruton tyrosine kinase inhibitors (BTKis) and the BCL2 inhibitor venetoclax have significantly improved outcomes for patients with chronic lymphocytic leukemia (CLL), especially those with biologically adverse disease. Patients with CLL resistant to their first targeted agent (TA) can be effectively treated with the alternative class. However, relapses are expected with second-line TA therapy, and…
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