Multiple myeloma with t(11;14)-associated immature phenotype has lower CD38 expression and higher BCL2 dependence

• Billy Bennett

CD38 expression on myeloma cells is a important issue affecting the early response to the anti-CD38 antibody daratumumab. Nevertheless, elements affecting CD38 expression in untreated a number of myeloma are usually not totally elucidated. On this research, we discovered that CD38 expression was considerably decrease in myeloma sufferers with the translocation t(11;14)-associated immature plasma cell…