Tag: dna hr block
Establishment and characterization of a fucosylated α-fetoprotein-specific monoclonal antibody: a potential application for clinical research
The Lens culinaris agglutinin (LCA)-reactive fraction of α-fetoprotein (AFP-L3) is a well-known cancer biomarker for hepatocellular carcinoma (HCC) with very high specificity. Because LCA recognizes only bi-antennary N-glycans with a core fucose, some of fucosylated AFP in HCC patients may not be detected. Then glycan antibodies, which recognize both specific glycan and protein, are desired…
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GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions
Hepatocellular carcinoma is essentially the most frequent major liver most cancers. Macroautophagy/autophagy inhibitors have been extensively studied in most cancers however, thus far, none has reached efficacy in medical trials. On this research, we demonstrated that GNS561, a brand new autophagy inhibitor, whose anticancer exercise was beforehand linked to lysosomal cell loss of life, displayed…
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Tryptophan-tagged peptide from serine threonine-protein kinase of Channa striatus improves antioxidant defence in L6 myotubes and attenuates caspase 3-dependent apoptotic response in zebrafish larvae
This research experiences the antioxidant property and molecular mechanism of a tryptophan-tagged peptide derived from a teleost fish Channa striatus of serine threonine-protein kinase (STPK). The peptide was tagged with tryptophan to boost the antioxidant property of STPK and named as IW13. The antioxidant exercise of IW13 peptide was investigated utilizing in vitro strategies akin…
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