Tag: dna testing kits
Establishment and characterization of a fucosylated α-fetoprotein-specific monoclonal antibody: a potential application for clinical research
The Lens culinaris agglutinin (LCA)-reactive fraction of α-fetoprotein (AFP-L3) is a well-known cancer biomarker for hepatocellular carcinoma (HCC) with very high specificity. Because LCA recognizes only bi-antennary N-glycans with a core fucose, some of fucosylated AFP in HCC patients may not be detected. Then glycan antibodies, which recognize both specific glycan and protein, are desired…
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The Impact of Chlorambucil and Valproic Acid on Cell Viability, Apoptosis and Expression of p21, HDM2, BCL2 and MCL1 Genes in Chronic Lymphocytic Leukemia
Malignant cells in power lymphocytic leukemia (CLL) present resistance to apoptosis, in addition to to chemotherapy, that are associated to deletions or mutations of TP53, excessive expression of MCL1 and BCL2 genes and different abnormalities. Thus, the principle aim of the current research was to evaluate the influence of chlorambucil (CLB) mixed with valproic acid (VPA), a identified antiepileptic drug…
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Regulation of distinct caspase-8 functions in retinal ganglion cells and astroglia in experimental glaucoma
Retinal ganglion cells (RGCs) increasing from the retina to the mind are main victims of neurodegeneration in glaucoma, a number one reason for blindness; nevertheless, the neighboring astroglia survive the glaucoma-related stress and promote neuroinflammation. In gentle of numerous capabilities of caspase-Eight in apoptosis, cell survival, and irritation, this research investigated the significance of caspase-Eight…
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