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High-Grade B-cell lymphomas with MYC and BCL2 translocations lack tumor-associated macrophages and PD-L1 expression: A possible noninflamed subgroup
We investigated the intratumoral supply of PD-L1 expression and the infiltration of tumor-associated macrophages (TAMs) in giant B-cell lymphomas (LBCL) with or with out MYC-translocation, in addition to doable correlations to BCL2- and BCL6-translocations and cell of origin (COO). 126 affected person samples have been studied in a cohort enriched for MYC translocated tumors with…
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NLRP3 and NLRP1 inflammasomes are up-regulated in patients with mesial temporal lobe epilepsy and may contribute to overexpression of caspase-1 and IL-β in sclerotic hippocampi
Irritation performs a job within the pathophysiology of mesial temporal lobe epilepsy (MTLE). Inflammasome pathways, together with the NLRP1 and NLRP3-induced ones, promote neuroinflammation and pyroptosis via interleukin (IL)-1β and caspase-1 motion. Analysis of NLRP1 in sclerotic hippocampi is scarce and there aren’t any knowledge on NLRP3 in human TLE. The intention of this research…
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