immpact-international

Mycobacterium tuberculosis Exploits Focal Adhesion Kinase to Induce Necrotic Cell Death and Inhibit Reactive Oxygen Species Production

Tuberculosis is a lethal, contagious respiratory illness that’s attributable to the pathogenic bacterium Mycobacterium tuberculosis (Mtb). Mtb is adept at manipulating and evading host immunity by hijacking alveolar macrophages, the primary line of protection towards inhaled pathogens, by regulating the mode and timing of host cell loss of life. It’s established that Mtb an infection actively blocks…

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immpact-international

Oxidative lesions modulate G-quadruplex stability and structure in the human BCL2 promoter

Misregulation of BCL2 expression has been noticed with many ailments and is related to mobile publicity to reactive oxygen species. A area upstream of the P1 promoter within the human BCL2 gene performs a significant function in regulating transcription. This G/C-rich area is very polymorphic and able to forming G-quadruplex constructions. Herein we report that…

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immpact-international

The Impact of Chlorambucil and Valproic Acid on Cell Viability, Apoptosis and Expression of p21, HDM2, BCL2 and MCL1 Genes in Chronic Lymphocytic Leukemia

Malignant cells in power lymphocytic leukemia (CLL) present resistance to apoptosis, in addition to to chemotherapy, that are associated to deletions or mutations of TP53, excessive expression of MCL1 and BCL2 genes and different abnormalities. Thus, the principle aim of the current research was to evaluate the influence of chlorambucil (CLB) mixed with valproic acid (VPA), a identified antiepileptic drug…

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