NLRP3 and NLRP1 inflammasomes are up-regulated in patients with mesial temporal lobe epilepsy and may contribute to overexpression of caspase-1 and IL-β in sclerotic hippocampi

• Billy Bennett

Irritation performs a job within the pathophysiology of mesial temporal lobe epilepsy (MTLE). Inflammasome pathways, together with the NLRP1 and NLRP3-induced ones, promote neuroinflammation and pyroptosis via interleukin (IL)-1β and caspase-1 motion. Analysis of NLRP1 in sclerotic hippocampi is scarce and there aren’t any knowledge on NLRP3 in human TLE. The intention of this research…