Tag: enzymes testing
Oxidative lesions modulate G-quadruplex stability and structure in the human BCL2 promoter
Misregulation of BCL2 expression has been noticed with many ailments and is related to mobile publicity to reactive oxygen species. A area upstream of the P1 promoter within the human BCL2 gene performs a significant function in regulating transcription. This G/C-rich area is very polymorphic and able to forming G-quadruplex constructions. Herein we report that…
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The Impact of Chlorambucil and Valproic Acid on Cell Viability, Apoptosis and Expression of p21, HDM2, BCL2 and MCL1 Genes in Chronic Lymphocytic Leukemia
Malignant cells in power lymphocytic leukemia (CLL) present resistance to apoptosis, in addition to to chemotherapy, that are associated to deletions or mutations of TP53, excessive expression of MCL1 and BCL2 genes and different abnormalities. Thus, the principle aim of the current research was to evaluate the influence of chlorambucil (CLB) mixed with valproic acid (VPA), a identified antiepileptic drug…
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Selective killing of human M1 macrophages by Smac mimetics alone and M2 macrophages by Smac mimetics and caspase inhibition
The inflammatory and anti inflammatory Mϕs have been implicated in lots of ailments together with rheumatoid arthritis, a number of sclerosis, and leprosy. Current research recommend focusing on Mϕ operate and activation could symbolize a possible goal to deal with these ailments. Herein, we investigated the impact of second mitochondria-derived activator of caspases (SMAC) mimetics…
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