IMMPACT:Initiative for Cell Mortality Programme Assessment.

Cell Death, Apoptosis, Oxidative stress, Caspase, BCL2

Prognostic influences of BCL1 and BCL2 expression on disease-free survival in breast cancer

Billy Bennett

We investigated the prognostic influences of BCL1 and BCL2 expression on disease-free survival in breast most cancers sufferers. BCL1 and BCL2 expression statuses had been assessed by immunohistochemistry utilizing tissue microarrays from 393 breast most cancers sufferers. The Kaplan-Meier estimator and log-rank check had been used for survival analyses. The Cox proportional hazards mannequin was…

Outcomes of patients with CLL sequentially resistant to both BCL2 and BTK inhibition

Billy Bennett

Covalent Bruton tyrosine kinase inhibitors (BTKis) and the BCL2 inhibitor venetoclax have significantly improved outcomes for patients with chronic lymphocytic leukemia (CLL), especially those with biologically adverse disease. Patients with CLL resistant to their first targeted agent (TA) can be effectively treated with the alternative class. However, relapses are expected with second-line TA therapy, and…