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Simultaneous Expression of Th1- and Treg-Associated Chemokine Genes and CD4 +, CD8 +, and Foxp3 + Cells in the Premalignant Lesions of 4NQO-Induced Mouse Tongue Tumorigenesis
Chemokines and cytokines in the tumor microenvironment influence immune cell infiltration and activation. To elucidate their role in immune cell recruitment during oral cancer development, we generated a mouse tongue cancer model using the carcinogen 4-nitroquinoline 1-oxide (4NQO) and investigated the carcinogenetic process and chemokine/cytokine gene expression kinetics in the mouse tongue. C57/BL6 mice were…
Read MoreEvaluation of the INDICAID COVID-19 Rapid Antigen Test in Symptomatic Populations and Asymptomatic Community Testing
As the COVID-19 pandemic progresses, there is an increasing need for rapid, accessible assays for SARS-CoV-2 detection. We present a clinical evaluation and real-world implementation of the INDICAID COVID-19 rapid antigen test (INDICAID rapid test). A multisite clinical evaluation of the INDICAID rapid test using prospectively collected nasal (bilateral anterior) swab samples from symptomatic subjects…
Read MoreEvaluating the genetic basis of anti-cancer property of Taxol in Saccharomyces cerevisiae model
Taxol has been regarded as one of the most successful anti-cancer drugs identified from natural sources to date. Although taxol is known to sensitize cells by stabilizing microtubules, its ability to cause DNA damage in peripheral blood lymphocytes, and to induce oxidative stress and apoptosis indicates that taxol may have other modes of cytotoxic action.…
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Synergistic efficacy of dual PI3K-d/g inhibitor Duvelisib with Bcl2 inhibitor Venetoclax in Richter’s Syndrome PDX models
A small subset of instances of continual lymphocytic leukemia undergoes transformation to diffuse massive B-cell lymphoma, Richter’s Syndrome (RS), which is related to a poor prognosis. Typical chemotherapy leads to restricted responses, underlining the necessity for novel therapeutic methods. Right here, we examine the ex-vivo and in vivo efficacy of the twin PI3K-d/g inhibitor Duvelisib…
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HMGB1 could restrict 1,3-β-glucan induced mice lung inflammation by affecting Beclin1 and Bcl2 interaction and promoting the autophagy of epithelial cells
Fungi had been microorganisms which are ubiquitous in a wide range of environments. Inhalation of fungi-contaminated natural mud led to hypersensitivity pneumonitis and may finally trigger irreversible pulmonary fibrosis. Research confirmed that sustaining the homeostasis of epithelial cells was important for defending the exogenous fungi invasion. HMGB1-dependent autophagy performed a vital function in sustaining cell…
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