HMGB1 could restrict 1,3-β-glucan induced mice lung inflammation by affecting Beclin1 and Bcl2 interaction and promoting the autophagy of epithelial cells

• Billy Bennett

Fungi had been microorganisms which are ubiquitous in a wide range of environments. Inhalation of fungi-contaminated natural mud led to hypersensitivity pneumonitis and may finally trigger irreversible pulmonary fibrosis. Research confirmed that sustaining the homeostasis of epithelial cells was important for defending the exogenous fungi invasion. HMGB1-dependent autophagy performed a vital function in sustaining cell…