Tag: particles definition
Concanavalin A Hepatitis
Concanavalin A (Con A) is a plant lectin that’s purified from jack beans. Con A binds to the mannose residues of assorted glycoproteins and prompts lymphocytes. When Con A is run to mice, liver damage that will depend on the activation of T lymphocytes by macrophages happens (Tiegs et al., 1992). Due to this fact, the mannequin may enable the examine of the pathophysiology of immunologically mediated…
Read More
Novel Hydroxytyrosol-Donepezil Hybrids as Potential Antioxidant and Neuroprotective Agents
It’s well-accepted that the endogenous antioxidant safety system progressively decays in aged individuals, and that the oxidative stress contributes to completely different neurodegenerative problems resembling Alzheimer’s Illnesses (AD). The decrease incidence of AD in international locations which function the Mediterranean Weight loss plan was related to the excessive consumption of additional virgin olive oil and…
Read More
GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions
Hepatocellular carcinoma is essentially the most frequent major liver most cancers. Macroautophagy/autophagy inhibitors have been extensively studied in most cancers however, thus far, none has reached efficacy in medical trials. On this research, we demonstrated that GNS561, a brand new autophagy inhibitor, whose anticancer exercise was beforehand linked to lysosomal cell loss of life, displayed…
Read More
Precursor B-Cell Acute Lymphoblastic Leukemia With MYC and BCL2 Rearrangements Presenting as Extensive Extranodal Disease in an Adolescent
Mixed rearrangements of MYC and BCL2 are uncommon in precursor B-cell acute lymphoblastic leukemia (B-ALL). A 14-year-old boy offered with swelling of the knee and face. Imaging revealed diffuse infiltration of lacrimal glands, parotid glands together with the in depth epidural illness. Morphology and immunophenotype of knee joint aspirate have been in keeping with precursor…
Read More