IMMPACT:Initiative for Cell Mortality Programme Assessment.

Cell Death, Apoptosis, Oxidative stress, Caspase, BCL2

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Precursor B-Cell Acute Lymphoblastic Leukemia With MYC and BCL2 Rearrangements Presenting as Extensive Extranodal Disease in an Adolescent

Mixed rearrangements of MYC and BCL2 are uncommon in precursor B-cell acute lymphoblastic leukemia (B-ALL). A 14-year-old boy offered with swelling of the knee and face. Imaging revealed diffuse infiltration of lacrimal glands, parotid glands together with the in depth epidural illness. Morphology and immunophenotype of knee joint aspirate have been in keeping with precursor…

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Real-time in situ monitoring of Lon and Caspase-3 for assessing the state of cardiomyocytes under hypoxic conditions via a novel Au-Se fluorescent nanoprobe

Real-time in situ monitoring of Lon and Caspase-3 for assessing the state of cardiomyocytes under hypoxic conditions via a novel Au-Se fluorescent nanoprobe

Myocardial dysfunction attributable to cardiomyocyte apoptosis beneath ischemic and hypoxic situations is the pathological foundation of most cardiovascular illnesses. Present prognosis of myocardial dysfunction nonetheless focuses on the symptomatic stage, often after the prevalence of the irreversible remodelling and purposeful impairment. Thus, early stage identification of the apoptotic cardiomyocytes induced by hypoxia is very important…

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