Tag: rna splicing
Probing the interaction of new and biologically active Pd(II) complex with DNA/BSA via joint experimental and computational studies along with thermodynamic, NLO, FMO and NBO analysis
Treatment with transition metal complexes is an efficient method to fight with cancer. Therefore, a new transition metal complex formulated as [Pd(1, 3-pn)(acac)]Cl (pn and acac stand for propylendiamine and acetylacetonate, respectively) was synthesized and analyzed using 1H NMR, Fourier transform infrared, electronic absorption spectroscopy techniques as well as elemental analysis and conductivity measurement. The geometry…
Read MoreIodixanol (Optiprep), an improved density gradient medium for the iso-osmotic isolation of rat liver peroxisomes
The suitability of Iodixanol {5,5′-[(2-hydroxy-1, 3-propanediyl)-bis(acetylamino)] bis-[N,N’-bis(2, 3-dihydroxypreopyl-2,4,6-triiodo-1,3-benzenecarboxamide)]}, a nonionic iodinated compound with a molecular weight of 1550, for the isolation of peroxisomes from rat liver was investigated. Centrifugation of light mitochondrial fractions in 20 to 40% (w/v) Iodixanol gradients, made iso-osmotic by the addition of sucrose, resulted in an excellent separation of peroxisomes from…
Read MoreLocalpdb- a Python package to manage protein structures and their annotations
The wealth of protein constructions collected within the Protein Knowledge Financial institution enabled large-scale research of their operate and evolution. Such research, nevertheless, require the era of personalized knowledge units combining the structural knowledge with miscellaneous accent sources offering purposeful, taxonomic, and different annotations. Sadly, the performance of at the moment obtainable instruments for the…
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Fe(III)-Shikonin Supramolecular Nanomedicine for Combined Therapy of Tumor via Ferroptosis and Necroptosis
A lot of the antitumor chemotherapeutic medication execute the therapeutic efficiency upon eliciting tumor cell apoptosis, which can trigger chemoresistance of tumors. Design of novel medication to eradicate apoptosis-resistant tumors through non-apoptotic cell dying pathways is promising for bettering the long-term chemotherapeutic efficacy. Herein, a Fe(III)-Shikonin metal-polyphenol-coordinated supramolecular nanomedicine for mixed remedy of tumor through…
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Real-time in situ monitoring of Lon and Caspase-3 for assessing the state of cardiomyocytes under hypoxic conditions via a novel Au-Se fluorescent nanoprobe
Myocardial dysfunction attributable to cardiomyocyte apoptosis beneath ischemic and hypoxic situations is the pathological foundation of most cardiovascular illnesses. Present prognosis of myocardial dysfunction nonetheless focuses on the symptomatic stage, often after the prevalence of the irreversible remodelling and purposeful impairment. Thus, early stage identification of the apoptotic cardiomyocytes induced by hypoxia is very important…
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