Synergistic efficacy of dual PI3K-d/g inhibitor Duvelisib with Bcl2 inhibitor Venetoclax in Richter’s Syndrome PDX models

A small subset of instances of continual lymphocytic leukemia undergoes transformation to diffuse massive B-cell lymphoma, Richter’s Syndrome (RS), which is related to a poor prognosis. Typical chemotherapy leads to restricted responses, underlining the necessity for novel therapeutic methods. Right here, we examine the ex-vivo and in vivo efficacy of the twin PI3K-d/g inhibitor Duvelisib…

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