Oxidative lesions modulate G-quadruplex stability and structure in the human BCL2 promoter

Misregulation of BCL2 expression has been noticed with many ailments and is related to mobile publicity to reactive oxygen species. A area upstream of the P1 promoter within the human BCL2 gene performs a significant function in regulating transcription. This G/C-rich area is very polymorphic and able to forming G-quadruplex constructions. Herein we report that…

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