Cooperative stabilisation of 14-3-3σ protein-protein interactions via covalent protein modification

14-3-Three proteins are an necessary household of hub proteins that play necessary roles in lots of mobile processes through a big community of interactions with associate proteins. Many of those protein-protein interactions (PPI) are implicated in human illnesses resembling most cancers and neurodegeneration. The stabilisation of chosen 14-3-Three PPIs utilizing drug-like ‘molecular glues’ is a novel therapeutic…

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