
The Impact of Chlorambucil and Valproic Acid on Cell Viability, Apoptosis and Expression of p21, HDM2, BCL2 and MCL1 Genes in Chronic Lymphocytic Leukemia
Diosgenin Protects In opposition to Kidney Damage and Mitochondrial Apoptosis Induced by 3-MCPD By way of the Regulation of ER Stress, Ca 2+ Homeostasis, and Bcl2 Expression
Affiliation of BCL2 polymorphisms and the IL19 single nucleotide polymorphism rs2243188 with systemic lupus erythematosus

An intronic danger SNP rs12454712 for central weight problems acts as an allele-specific enhancer to control BCL2 expression
Genome-wide affiliation research (GWASs) have reproducibly related the SNP rs12454712 with waist-to-hip ratio adjusted for physique mass index (WHRadjBMI), however the useful function underlying this intronic variant is unknown. Integrative genomic and epigenomic analyses supported rs12454712 as a useful unbiased variant. We additional demonstrated that rs12454712 acted as an allele-specific enhancer regulating expression of its situated gene BCL2 through the use of dual-luciferase reporter assays and CRISPR-Cas9.
Particularly, rs12454712-C allele can bind transcription issue ZNF329, which effectively elevates the enhancer exercise and will increase BCL2 expression. Pulling down Bcl2 in 3T3-L1 cells led to the down-regulation of adipogenic differentiation marker genes and elevated cell apoptosis. Vital adverse correlation between BCL2 expression in subcutaneous adipose tissues and weight problems was noticed. Our findings illustrate the molecular mechanisms behind the intronic SNP rs12454712 for central weight problems, which might be a possible and promising goal for creating acceptable therapies.
HIV Nef-mediated Ubiquitination of BCL2: Implications in Autophagy and Apoptosis
![]() Human Bcl2 antagonist of cell death(BAD) ELISA kit |
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CSB-EL002528HU-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
Description: Quantitativesandwich ELISA kit for measuring Human Bcl2 antagonist of cell death (BAD) in samples from serum, plasma, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
![]() Human Bcl2 antagonist of cell death(BAD) ELISA kit |
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1-CSB-EL002528HU | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human Bcl2 antagonist of cell death(BAD) in samples from serum, plasma, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
![]() Mouse Bcl2 antagonist of cell death(BAD) ELISA kit |
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CSB-EL002528MO-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
Description: Quantitativesandwich ELISA kit for measuring Mouse Bcl2 antagonist of cell death (BAD) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
![]() Mouse Bcl2 antagonist of cell death(BAD) ELISA kit |
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1-CSB-EL002528MO | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Mouse Bcl2 antagonist of cell death(BAD) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
![]() Human BAD(Bcl2 antagonist of cell death) ELISA Kit |
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EH1736 | FN Test | 96T | EUR 628.92 |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml |
![]() Human Bcl2 antagonist of cell death, BAD ELISA KIT |
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ELI-34743h | Lifescience Market | 96 Tests | EUR 988.8 |
![]() ELISA kit for Human Bcl2 antagonist of cell death |
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EK3600 | SAB | 96 tests | EUR 804 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Bcl2 antagonist of cell death in samples from serum, plasma, tissue homogenates and other biological fluids. |
![]() Mouse Bcl2 antagonist of cell death, Bad ELISA KIT |
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ELI-24466m | Lifescience Market | 96 Tests | EUR 1038 |
![]() Human Bcl2 antagonist of cell death(BAD)ELISA kit |
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YLA4408HU-48T | Shanghai YL Biotech | 48T | EUR 435 |
![]() Human Bcl2 antagonist of cell death(BAD)ELISA kit |
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YLA4408HU-96T | Shanghai YL Biotech | 96T | EUR 562.5 |
![]() Mouse Bcl2 antagonist of cell death(BAD)ELISA kit |
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YLA1852MO-48T | Shanghai YL Biotech | 48T | EUR 465 |
![]() Mouse Bcl2 antagonist of cell death(BAD)ELISA kit |
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YLA1852MO-96T | Shanghai YL Biotech | 96T | EUR 600 |
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7-01201 | CHI Scientific | 10µg | Ask for price |
![]() Recombinant Rat Leptin Triple Antagonist |
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7-01202 | CHI Scientific | 50µg | Ask for price |
![]() Recombinant Rat Leptin Triple Antagonist |
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7-01203 | CHI Scientific | 1mg | Ask for price |
![]() Rat BCL2 Antagonist/Killer 1 (BAK1) ELISA Kit |
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abx256729-96tests | Abbexa | 96 tests | EUR 801.6 |
![]() Recombinant Ovine Prolactin Antagonist |
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7-01450 | CHI Scientific | 10µg | Ask for price |
![]() Recombinant Ovine Prolactin Antagonist |
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7-01451 | CHI Scientific | 50µg | Ask for price |
![]() Recombinant Ovine Prolactin Antagonist |
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7-01452 | CHI Scientific | 1mg | Ask for price |
![]() Rat BAK1(BCL2 Antagonist/Killer 1) ELISA Kit |
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ER0760 | FN Test | 96T | EUR 628.92 |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.469 ng/ml |
![]() Recombinant Human Leptin Triple Antagonist |
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CG072-020 | GenDepot | 20ug | EUR 351.6 |
![]() Recombinant Human Leptin Triple Antagonist |
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CG072-100 | GenDepot | 100ug | EUR 489.6 |
![]() Recombinant Human Leptin Triple Antagonist |
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CG072-101 | GenDepot | 1mg | EUR 2652 |
![]() Recombinant Human Leptin Triple Antagonist |
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7-01186 | CHI Scientific | 10µg | Ask for price |
![]() Recombinant Human Leptin Triple Antagonist |
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7-01187 | CHI Scientific | 50µg | Ask for price |
![]() Recombinant Human Leptin Triple Antagonist |
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7-01188 | CHI Scientific | 1mg | Ask for price |
![]() Recombinant Mouse Leptin Triple Antagonist |
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7-01195 | CHI Scientific | 10µg | Ask for price |
![]() Recombinant Mouse Leptin Triple Antagonist |
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7-01196 | CHI Scientific | 50µg | Ask for price |
![]() Recombinant Mouse Leptin Triple Antagonist |
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7-01197 | CHI Scientific | 1mg | Ask for price |
![]() Recombinant Ovine Leptin Triple Antagonist |
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7-01207 | CHI Scientific | 10µg | Ask for price |
![]() Recombinant Ovine Leptin Triple Antagonist |
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7-01208 | CHI Scientific | 50µg | Ask for price |
![]() Recombinant Ovine Leptin Triple Antagonist |
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7-01209 | CHI Scientific | 1mg | Ask for price |
![]() ELISA kit for Rat BAK1 (BCL2 Antagonist/Killer 1) |
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E-EL-R0097 | Elabscience Biotech | 1 plate of 96 wells | EUR 640.8 |
Description: A sandwich ELISA kit for quantitative measurement of Rat BAK1 (BCL2 Antagonist/Killer 1) in samples from Serum, Plasma, Cell supernatant |
![]() Bcl2 Antagonist/Killer 1 (BAK1) Antibody |
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20-abx175548 | Abbexa |
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![]() Bcl2 Antagonist/Killer 1 (BAK1) Antibody |
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20-abx171396 | Abbexa |
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![]() Bcl2 Antagonist/Killer 1 (BAK1) Antibody |
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20-abx211066 | Abbexa |
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![]() Bcl2 Antagonist/Killer 1 (BAK1) Antibody |
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20-abx211310 | Abbexa |
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![]() Bcl2 Antagonist/Killer 1 (BAK1) Antibody |
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20-abx326092 | Abbexa |
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![]() Bcl2 Antagonist/Killer 1 (BAK1) Antibody |
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abx330690-100ul | Abbexa | 100 ul | EUR 510 |
![]() Bcl2 Antagonist/Killer 1 (BAK1) Antibody |
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20-abx111203 | Abbexa |
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![]() Recombinant Human Leptin Quadruple Antagonist |
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7-01192 | CHI Scientific | 10µg | Ask for price |
![]() Recombinant Human Leptin Quadruple Antagonist |
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7-01193 | CHI Scientific | 50µg | Ask for price |
![]() Recombinant Human Leptin Quadruple Antagonist |
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7-01194 | CHI Scientific | 1mg | Ask for price |
![]() Recombinant Ovine Leptin Quadruple Antagonist |
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7-01213 | CHI Scientific | 10µg | Ask for price |
![]() Recombinant Ovine Leptin Quadruple Antagonist |
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7-01214 | CHI Scientific | 50µg | Ask for price |
![]() Recombinant Ovine Leptin Quadruple Antagonist |
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7-01215 | CHI Scientific | 1mg | Ask for price |
![]() Recombinant Ovine Prolactin Antagonist, Mutant |
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7-01453 | CHI Scientific | 10µg | Ask for price |
![]() Recombinant Ovine Prolactin Antagonist, Mutant |
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7-01454 | CHI Scientific | 50µg | Ask for price |
![]() Recombinant Ovine Prolactin Antagonist, Mutant |
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7-01455 | CHI Scientific | 1mg | Ask for price |
![]() Recombinant Pegylated Rat Leptin Triple Antagonist, Pegylated |
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7-01204 | CHI Scientific | 5µg | Ask for price |
![]() Recombinant Pegylated Rat Leptin Triple Antagonist, Pegylated |
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7-01205 | CHI Scientific | 20µg | Ask for price |
![]() Recombinant Pegylated Rat Leptin Triple Antagonist, Pegylated |
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7-01206 | CHI Scientific | 1mg | Ask for price |
![]() BAK1 ELISA Kit| Rat BCL2 Antagonist/Killer 1 ELISA Kit |
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EF017559 | Lifescience Market | 96 Tests | EUR 826.8 |
![]() Human Bcl2 Antagonist/Killer 1 (BAK1) Protein |
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20-abx652648 | Abbexa |
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![]() Recombinant Interleukin 1 Receptor Antagonist (IL1RA) |
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4-RPA223Bo01 | Cloud-Clone |
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Description: Recombinant Bovine Interleukin 1 Receptor Antagonist expressed in: E.coli |
![]() Recombinant Interleukin 1 Receptor Antagonist (IL1RA) |
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4-RPA223Ca01 | Cloud-Clone |
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Description: Recombinant Dog Interleukin 1 Receptor Antagonist expressed in: E.coli |
![]() Recombinant Interleukin 1 Receptor Antagonist (IL1RA) |
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4-RPA223Eq01 | Cloud-Clone |
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Description: Recombinant Horse Interleukin 1 Receptor Antagonist expressed in: E.coli |
![]() Recombinant Interleukin 1 Receptor Antagonist (IL1RA) |
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4-RPA223Hu01 | Cloud-Clone |
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Description: Recombinant Human Interleukin 1 Receptor Antagonist expressed in: E.coli |
![]() Recombinant Interleukin 1 Receptor Antagonist (IL1RA) |
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4-RPA223Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Interleukin 1 Receptor Antagonist expressed in: E.coli |
![]() Recombinant Interleukin 1 Receptor Antagonist (IL1RA) |
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4-RPA223Po01 | Cloud-Clone |
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Description: Recombinant Pig Interleukin 1 Receptor Antagonist expressed in: E.coli |
![]() Recombinant Interleukin 1 Receptor Antagonist (IL1RA) |
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4-RPA223Rb01 | Cloud-Clone |
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Description: Recombinant Rabbit Interleukin 1 Receptor Antagonist expressed in: E.coli |
![]() Recombinant Interleukin 1 Receptor Antagonist (IL1RA) |
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4-RPA223Si01 | Cloud-Clone |
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Description: Recombinant Simian Interleukin 1 Receptor Antagonist expressed in: E.coli |
![]() Recombinant Human Leptin Triple Antagonist, Pegylated |
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7-01189 | CHI Scientific | 5µg | Ask for price |
![]() Recombinant Human Leptin Triple Antagonist, Pegylated |
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7-01190 | CHI Scientific | 20µg | Ask for price |
![]() Recombinant Human Leptin Triple Antagonist, Pegylated |
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7-01191 | CHI Scientific | 1mg | Ask for price |
![]() Recombinant Ovine Leptin Triple Antagonist, Pegylated |
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7-01210 | CHI Scientific | 5µg | Ask for price |
![]() Recombinant Ovine Leptin Triple Antagonist, Pegylated |
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7-01211 | CHI Scientific | 20µg | Ask for price |
![]() Recombinant Ovine Leptin Triple Antagonist, Pegylated |
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7-01212 | CHI Scientific | 1mg | Ask for price |
![]() Human Bcl2 Antagonist/Killer 1 (BAK1) CLIA Kit |
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abx196477-96tests | Abbexa | 96 tests | EUR 990 |
![]() Human Bcl2 Antagonist/Killer 1 (BAK1) CLIA Kit |
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20-abx493620 | Abbexa |
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