
The Impact of Chlorambucil and Valproic Acid on Cell Viability, Apoptosis and Expression of p21, HDM2, BCL2 and MCL1 Genes in Chronic Lymphocytic Leukemia
Diosgenin Protects In opposition to Kidney Damage and Mitochondrial Apoptosis Induced by 3-MCPD By way of the Regulation of ER Stress, Ca 2+ Homeostasis, and Bcl2 Expression
Affiliation of BCL2 polymorphisms and the IL19 single nucleotide polymorphism rs2243188 with systemic lupus erythematosus

An intronic danger SNP rs12454712 for central weight problems acts as an allele-specific enhancer to control BCL2 expression
Genome-wide affiliation research (GWASs) have reproducibly related the SNP rs12454712 with waist-to-hip ratio adjusted for physique mass index (WHRadjBMI), however the useful function underlying this intronic variant is unknown. Integrative genomic and epigenomic analyses supported rs12454712 as a useful unbiased variant. We additional demonstrated that rs12454712 acted as an allele-specific enhancer regulating expression of its situated gene BCL2 through the use of dual-luciferase reporter assays and CRISPR-Cas9.
Particularly, rs12454712-C allele can bind transcription issue ZNF329, which effectively elevates the enhancer exercise and will increase BCL2 expression. Pulling down Bcl2 in 3T3-L1 cells led to the down-regulation of adipogenic differentiation marker genes and elevated cell apoptosis. Vital adverse correlation between BCL2 expression in subcutaneous adipose tissues and weight problems was noticed. Our findings illustrate the molecular mechanisms behind the intronic SNP rs12454712 for central weight problems, which might be a possible and promising goal for creating acceptable therapies.
HIV Nef-mediated Ubiquitination of BCL2: Implications in Autophagy and Apoptosis
![]() Human Bcl2 antagonist of cell death(BAD) ELISA kit |
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CSB-EL002528HU-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
Description: Quantitativesandwich ELISA kit for measuring Human Bcl2 antagonist of cell death (BAD) in samples from serum, plasma, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
![]() Human Bcl2 antagonist of cell death(BAD) ELISA kit |
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1-CSB-EL002528HU | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human Bcl2 antagonist of cell death(BAD) in samples from serum, plasma, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
![]() Mouse Bcl2 antagonist of cell death(BAD) ELISA kit |
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CSB-EL002528MO-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
Description: Quantitativesandwich ELISA kit for measuring Mouse Bcl2 antagonist of cell death (BAD) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
![]() Mouse Bcl2 antagonist of cell death(BAD) ELISA kit |
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1-CSB-EL002528MO | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Mouse Bcl2 antagonist of cell death(BAD) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
![]() Human BAD(Bcl2 antagonist of cell death) ELISA Kit |
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EH1736 | FN Test | 96T | EUR 628.92 |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml |
![]() ELISA kit for Human Bcl2 antagonist of cell death |
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EK3600 | SAB | 96 tests | EUR 804 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Bcl2 antagonist of cell death in samples from serum, plasma, tissue homogenates and other biological fluids. |
![]() Mouse Bcl2 antagonist of cell death, Bad ELISA KIT |
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ELI-24466m | Lifescience Market | 96 Tests | EUR 1038 |
![]() Human Bcl2 antagonist of cell death, BAD ELISA KIT |
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ELI-34743h | Lifescience Market | 96 Tests | EUR 988.8 |
![]() Human Bcl2 antagonist of cell death(BAD)ELISA kit |
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YLA4408HU-48T | Shanghai YL Biotech | 48T | EUR 435 |
![]() Human Bcl2 antagonist of cell death(BAD)ELISA kit |
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YLA4408HU-96T | Shanghai YL Biotech | 96T | EUR 562.5 |
![]() Mouse Bcl2 antagonist of cell death(BAD)ELISA kit |
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YLA1852MO-48T | Shanghai YL Biotech | 48T | EUR 465 |
![]() Mouse Bcl2 antagonist of cell death(BAD)ELISA kit |
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YLA1852MO-96T | Shanghai YL Biotech | 96T | EUR 600 |
![]() Bcl2-Interacting Mediator of Cell Death (BIM) Antibody |
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20-abx008368 | Abbexa |
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![]() Bcl2-Interacting Mediator of Cell Death (BIM) Antibody |
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20-abx123408 | Abbexa |
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![]() BCL2 Associated Agonist of Cell Death (BAD) Antibody |
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20-abx111204 | Abbexa |
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![]() BCL2 Associated Agonist Of Cell Death (BAD) Antibody |
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20-abx329564 | Abbexa |
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![]() BCL2 Associated Agonist Of Cell Death (BAD) Antibody |
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20-abx329911 | Abbexa |
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![]() BCL2 Associated Agonist Of Cell Death (BAD) Antibody |
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abx332054-100ul | Abbexa | 100 ul | EUR 510 |
![]() BCL2 Associated Agonist Of Cell Death (BAD) Antibody |
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abx332057-100ul | Abbexa | 100 ul | EUR 510 |
![]() BCL2 Associated Agonist Of Cell Death (BAD) Antibody |
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abx332059-100ul | Abbexa | 100 ul | EUR 510 |
![]() Bcl2-Associated Agonist Of Cell Death (BAD) Antibody |
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abx230784-100ug | Abbexa | 100 ug | EUR 577.2 |
![]() BCL2 Associated Agonist Of Cell Death (BAD) Antibody |
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20-abx326401 | Abbexa |
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![]() BCL2 Associated Agonist Of Cell Death (BAD) Antibody |
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20-abx328193 | Abbexa |
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![]() BCL2 Associated Agonist Of Cell Death (BAD) Antibody |
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20-abx328450 | Abbexa |
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![]() Bcl2-Interacting Mediator of Cell Death (BIM) Antibody |
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abx432408-200ul | Abbexa | 200 ul | EUR 460.8 |
![]() BCL2 Associated Agonist Of Cell Death (BAD) Antibody |
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20-abx339824 | Abbexa |
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![]() Bcl2-Interacting Mediator of Cell Death (BIM) Antibody |
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abx412140-01mg | Abbexa | 0.1 mg | EUR 844.8 |
![]() Bcl2-Interacting Mediator of Cell Death (BIM) Antibody |
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abx412598-01mg | Abbexa | 0.1 mg | EUR 610.8 |
![]() Human BAD/ Bcl2-associated agonist of cell death ELISA Kit |
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E0251Hu | Sunlong | 1 Kit | EUR 726 |
![]() Recombinant Bcl2 Associated Death Promoter (BAD) |
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4-RPC337Hu01 | Cloud-Clone |
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Description: Recombinant Human Bcl2 Associated Death Promoter expressed in: E.coli |
![]() BCL2 Associated Agonist Of Cell Death Phospho-Ser112 (BAD pS112) Antibody |
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abx333225-100ul | Abbexa | 100 ul | EUR 560.4 |
![]() BCL2 Associated Agonist Of Cell Death Phospho-Ser155 (BAD pS155) Antibody |
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abx333230-100ul | Abbexa | 100 ul | EUR 560.4 |
![]() BCL2 Associated Agonist Of Cell Death Phospho-Ser136 (BAD pS136) Antibody |
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abx333274-100ul | Abbexa | 100 ul | EUR 560.4 |
![]() BCL2 Associated Agonist Of Cell Death Phospho-Ser134 (BAD pS134) Antibody |
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20-abx329565 | Abbexa |
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![]() BCL2 Associated Agonist Of Cell Death Phospho-Ser91 (BAD pS91) Antibody |
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20-abx330028 | Abbexa |
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![]() BCL2 Associated Agonist Of Cell Death Phospho-Ser136 (BAD pS136) Antibody |
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20-abx328451 | Abbexa |
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![]() BCL2 Associated Agonist Of Cell Death Phospho-Ser112 (BAD pS112) Antibody |
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20-abx328933 | Abbexa |
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![]() BCL2 Associated Agonist Of Cell Death Phospho-Ser155 (BAD pS155) Antibody |
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20-abx329155 | Abbexa |
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![]() Rat B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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DLR-Bcl2-Ra-48T | DL Develop | 48T | EUR 544.8 |
Description: A sandwich quantitative ELISA assay kit for detection of Rat B-Cell Leukemia/Lymphoma 2 (Bcl2) in samples from serum, plasma, tissue homogenates or other biological fluids. |
![]() Rat B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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DLR-Bcl2-Ra-96T | DL Develop | 96T | EUR 704.4 |
Description: A sandwich quantitative ELISA assay kit for detection of Rat B-Cell Leukemia/Lymphoma 2 (Bcl2) in samples from serum, plasma, tissue homogenates or other biological fluids. |
![]() Rat B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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RD-Bcl2-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 540 |
![]() Rat B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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RD-Bcl2-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 746.4 |
![]() Rat B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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RDR-Bcl2-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 564 |
![]() Rat B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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RDR-Bcl2-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 781.2 |
![]() Rat Bcl2 Associated Death Promoter ELISA kit |
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E02B0633-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Rat Bcl2 Associated Death Promoter in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Rat Bcl2 Associated Death Promoter ELISA kit |
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E02B0633-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Rat Bcl2 Associated Death Promoter in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Rat Bcl2 Associated Death Promoter ELISA kit |
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E02B0633-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Rat Bcl2 Associated Death Promoter in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Rat BCL2 Antagonist/Killer 1 (BAK1) ELISA Kit |
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abx256729-96tests | Abbexa | 96 tests | EUR 801.6 |
![]() Rat BAK1(BCL2 Antagonist/Killer 1) ELISA Kit |
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ER0760 | FN Test | 96T | EUR 628.92 |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.469 ng/ml |
![]() Bcl2 Antagonist/Killer 1 (BAK1) Antibody |
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20-abx171396 | Abbexa |
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![]() BCL2-Antagonist/Killer 1 (BAK1) Antibody |
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20-abx000593 | Abbexa |
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![]() BCL2-Antagonist/Killer 1 (BAK1) Antibody |
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20-abx125297 | Abbexa |
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![]() BCL2-Antagonist/Killer 1 (BAK1) Antibody |
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20-abx126839 | Abbexa |
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![]() Bcl2 Antagonist/Killer 1 (BAK1) Antibody |
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20-abx111203 | Abbexa |
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![]() Bcl2 Antagonist/Killer 1 (BAK1) Antibody |
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abx330690-100ul | Abbexa | 100 ul | EUR 510 |
![]() Bcl2 Antagonist/Killer 1 (BAK1) Antibody |
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20-abx326092 | Abbexa |
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![]() BCL2-Antagonist/Killer 1 (BAK1) Antibody |
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abx431121-200ul | Abbexa | 200 ul | EUR 460.8 |
![]() Bcl2 Antagonist/Killer 1 (BAK1) Antibody |
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20-abx211066 | Abbexa |
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![]() Bcl2 Antagonist/Killer 1 (BAK1) Antibody |
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20-abx211310 | Abbexa |
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![]() Bcl2 Antagonist/Killer 1 (BAK1) Antibody |
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20-abx175548 | Abbexa |
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![]() Bcl2-Associated Agonist Of Cell Death Phospho-Ser91/128 (BAD pS91/128) Antibody |
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20-abx012475 | Abbexa |
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![]() Custom production of antibodies in 5 Rats using customer supplied antigen (std 63 days protocol) |
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RAT-5 | Alpha Diagnostics | 1 | EUR 1365.6 |
![]() Bovine B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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DLR-Bcl2-b-48T | DL Develop | 48T | EUR 591.6 |
Description: A sandwich quantitative ELISA assay kit for detection of Bovine B-Cell Leukemia/Lymphoma 2 (Bcl2) in samples from serum, plasma, tissue homogenates or other biological fluids. |
![]() Bovine B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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DLR-Bcl2-b-96T | DL Develop | 96T | EUR 769.2 |
Description: A sandwich quantitative ELISA assay kit for detection of Bovine B-Cell Leukemia/Lymphoma 2 (Bcl2) in samples from serum, plasma, tissue homogenates or other biological fluids. |
![]() Human B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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DLR-Bcl2-Hu-48T | DL Develop | 48T | EUR 510 |
Description: A sandwich quantitative ELISA assay kit for detection of Human B-Cell Leukemia/Lymphoma 2 (Bcl2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
![]() Human B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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DLR-Bcl2-Hu-96T | DL Develop | 96T | EUR 657.6 |
Description: A sandwich quantitative ELISA assay kit for detection of Human B-Cell Leukemia/Lymphoma 2 (Bcl2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
![]() Mouse B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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DLR-Bcl2-Mu-48T | DL Develop | 48T | EUR 522 |
Description: A sandwich quantitative ELISA assay kit for detection of Mouse B-Cell Leukemia/Lymphoma 2 (Bcl2) in samples from serum, plasma, tissue homogenates or other biological fluids. |
![]() Mouse B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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DLR-Bcl2-Mu-96T | DL Develop | 96T | EUR 673.2 |
Description: A sandwich quantitative ELISA assay kit for detection of Mouse B-Cell Leukemia/Lymphoma 2 (Bcl2) in samples from serum, plasma, tissue homogenates or other biological fluids. |
![]() Bovine B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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RD-Bcl2-b-48Tests | Reddot Biotech | 48 Tests | EUR 592.8 |
![]() Bovine B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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RD-Bcl2-b-96Tests | Reddot Biotech | 96 Tests | EUR 820.8 |