
The Impact of Chlorambucil and Valproic Acid on Cell Viability, Apoptosis and Expression of p21, HDM2, BCL2 and MCL1 Genes in Chronic Lymphocytic Leukemia
Diosgenin Protects In opposition to Kidney Damage and Mitochondrial Apoptosis Induced by 3-MCPD By way of the Regulation of ER Stress, Ca 2+ Homeostasis, and Bcl2 Expression
Affiliation of BCL2 polymorphisms and the IL19 single nucleotide polymorphism rs2243188 with systemic lupus erythematosus

An intronic danger SNP rs12454712 for central weight problems acts as an allele-specific enhancer to control BCL2 expression
Genome-wide affiliation research (GWASs) have reproducibly related the SNP rs12454712 with waist-to-hip ratio adjusted for physique mass index (WHRadjBMI), however the useful function underlying this intronic variant is unknown. Integrative genomic and epigenomic analyses supported rs12454712 as a useful unbiased variant. We additional demonstrated that rs12454712 acted as an allele-specific enhancer regulating expression of its situated gene BCL2 through the use of dual-luciferase reporter assays and CRISPR-Cas9.
Particularly, rs12454712-C allele can bind transcription issue ZNF329, which effectively elevates the enhancer exercise and will increase BCL2 expression. Pulling down Bcl2 in 3T3-L1 cells led to the down-regulation of adipogenic differentiation marker genes and elevated cell apoptosis. Vital adverse correlation between BCL2 expression in subcutaneous adipose tissues and weight problems was noticed. Our findings illustrate the molecular mechanisms behind the intronic SNP rs12454712 for central weight problems, which might be a possible and promising goal for creating acceptable therapies.
HIV Nef-mediated Ubiquitination of BCL2: Implications in Autophagy and Apoptosis
![]() Mouse Bcl2 antagonist of cell death(BAD) ELISA kit |
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1-CSB-EL002528MO | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Mouse Bcl2 antagonist of cell death(BAD) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
![]() Human Bcl2 Antagonist Of Cell Death (BAD) ELISA Kit |
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abx517501-96tests | Abbexa | 96 tests | EUR 707 |
![]() Mouse Bcl2 Antagonist Of Cell Death (BAD) ELISA Kit |
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abx255207-96tests | Abbexa | 96 tests | EUR 707 |
![]() Human Bcl2 Antagonist Of Cell Death (BAD) ELISA Kit |
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abx251039-96tests | Abbexa | 96 tests | EUR 707 |
![]() ELISA kit for Human Bcl2 antagonist of cell death |
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EK3600 | SAB | 96 tests | EUR 670 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Bcl2 antagonist of cell death in samples from serum, plasma, tissue homogenates and other biological fluids. |
![]() Human BAD(Bcl2 antagonist of cell death) ELISA Kit |
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EH1736 | FN Test | 96T | EUR 524.1 |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml |
![]() BCL2 Associated Agonist of Cell Death (BAD) Antibody |
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20-abx111204 | Abbexa |
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![]() Bcl2-Interacting Mediator of Cell Death (BIM) Antibody |
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20-abx123408 | Abbexa |
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![]() Bcl2-Interacting Mediator of Cell Death (BIM) Antibody |
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20-abx008368 | Abbexa |
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![]() Bcl2-Interacting Mediator of Cell Death (BIM) Antibody |
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abx412140-01mg | Abbexa | 0.1 mg | EUR 704 |
![]() Bcl2-Interacting Mediator of Cell Death (BIM) Antibody |
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abx412598-01mg | Abbexa | 0.1 mg | EUR 509 |
![]() Bcl2-Interacting Mediator of Cell Death (BIM) Antibody |
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abx432408-200ul | Abbexa | 200 ul | EUR 384 |
![]() Bcl2-Associated Agonist Of Cell Death (BAD) Antibody |
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abx230784-100ug | Abbexa | 100 ug | EUR 481 |
![]() BCL2 Associated Agonist Of Cell Death (BAD) Antibody |
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20-abx339824 | Abbexa |
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![]() BCL2 Associated Agonist Of Cell Death (BAD) Antibody |
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20-abx329564 | Abbexa |
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![]() BCL2 Associated Agonist Of Cell Death (BAD) Antibody |
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20-abx329911 | Abbexa |
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![]() BCL2 Associated Agonist Of Cell Death (BAD) Antibody |
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abx332054-100ul | Abbexa | 100 ul | EUR 425 |
![]() BCL2 Associated Agonist Of Cell Death (BAD) Antibody |
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abx332057-100ul | Abbexa | 100 ul | EUR 425 |
![]() BCL2 Associated Agonist Of Cell Death (BAD) Antibody |
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abx332059-100ul | Abbexa | 100 ul | EUR 425 |
![]() BCL2 Associated Agonist Of Cell Death (BAD) Antibody |
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20-abx326401 | Abbexa |
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![]() BCL2 Associated Agonist Of Cell Death (BAD) Antibody |
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20-abx328193 | Abbexa |
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![]() BCL2 Associated Agonist Of Cell Death (BAD) Antibody |
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20-abx328450 | Abbexa |
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![]() Human BAD/ Bcl2-associated agonist of cell death ELISA Kit |
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E0251Hu | Sunlong | 1 Kit | EUR 605 |
![]() Recombinant Bcl2 Associated Death Promoter (BAD) |
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4-RPC337Hu01 | Cloud-Clone |
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Description: Recombinant Human Bcl2 Associated Death Promoter expressed in: E.coli |
![]() Rat B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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DLR-Bcl2-Ra-48T | DL Develop | 48T | EUR 454 |
Description: A sandwich quantitative ELISA assay kit for detection of Rat B-Cell Leukemia/Lymphoma 2 (Bcl2) in samples from serum, plasma, tissue homogenates or other biological fluids. |
![]() Rat B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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DLR-Bcl2-Ra-96T | DL Develop | 96T | EUR 587 |
Description: A sandwich quantitative ELISA assay kit for detection of Rat B-Cell Leukemia/Lymphoma 2 (Bcl2) in samples from serum, plasma, tissue homogenates or other biological fluids. |
![]() Rat B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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RD-Bcl2-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 450 |
![]() Rat B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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RD-Bcl2-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 622 |
![]() Rat B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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RDR-Bcl2-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 470 |
![]() Rat B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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RDR-Bcl2-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 651 |
![]() BCL2 Associated Agonist Of Cell Death Phospho-Ser134 (BAD pS134) Antibody |
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20-abx329565 | Abbexa |
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![]() BCL2 Associated Agonist Of Cell Death Phospho-Ser91 (BAD pS91) Antibody |
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20-abx330028 | Abbexa |
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![]() BCL2 Associated Agonist Of Cell Death Phospho-Ser112 (BAD pS112) Antibody |
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abx333225-100ul | Abbexa | 100 ul | EUR 467 |
![]() BCL2 Associated Agonist Of Cell Death Phospho-Ser155 (BAD pS155) Antibody |
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abx333230-100ul | Abbexa | 100 ul | EUR 467 |
![]() BCL2 Associated Agonist Of Cell Death Phospho-Ser136 (BAD pS136) Antibody |
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abx333274-100ul | Abbexa | 100 ul | EUR 467 |
![]() BCL2 Associated Agonist Of Cell Death Phospho-Ser136 (BAD pS136) Antibody |
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20-abx328451 | Abbexa |
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![]() BCL2 Associated Agonist Of Cell Death Phospho-Ser112 (BAD pS112) Antibody |
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20-abx328933 | Abbexa |
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![]() BCL2 Associated Agonist Of Cell Death Phospho-Ser155 (BAD pS155) Antibody |
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20-abx329155 | Abbexa |
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![]() Rat Bcl2 Associated Death Promoter ELISA kit |
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E02B0633-192T | BlueGene | 192 tests | EUR 1270 |
Description: A competitive ELISA for quantitative measurement of Rat Bcl2 Associated Death Promoter in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Rat Bcl2 Associated Death Promoter ELISA kit |
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E02B0633-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
Description: A competitive ELISA for quantitative measurement of Rat Bcl2 Associated Death Promoter in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Rat Bcl2 Associated Death Promoter ELISA kit |
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E02B0633-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
Description: A competitive ELISA for quantitative measurement of Rat Bcl2 Associated Death Promoter in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
![]() Bcl2-Associated Agonist Of Cell Death Phospho-Ser91/128 (BAD pS91/128) Antibody |
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20-abx012475 | Abbexa |
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![]() Rat BCL2 Antagonist/Killer 1 (BAK1) ELISA Kit |
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abx256729-96tests | Abbexa | 96 tests | EUR 668 |
![]() Rat BAK1(BCL2 Antagonist/Killer 1) ELISA Kit |
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ER0760 | FN Test | 96T | EUR 524.1 |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.469 ng/ml |
![]() BCL2-Antagonist/Killer 1 (BAK1) Antibody |
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20-abx125297 | Abbexa |
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![]() BCL2-Antagonist/Killer 1 (BAK1) Antibody |
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20-abx126839 | Abbexa |
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![]() Bcl2 Antagonist/Killer 1 (BAK1) Antibody |
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20-abx111203 | Abbexa |
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![]() BCL2-Antagonist/Killer 1 (BAK1) Antibody |
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20-abx000593 | Abbexa |
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![]() BCL2-Antagonist/Killer 1 (BAK1) Antibody |
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abx431121-200ul | Abbexa | 200 ul | EUR 384 |
![]() Bcl2 Antagonist/Killer 1 (BAK1) Antibody |
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20-abx171396 | Abbexa |
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![]() Bcl2 Antagonist/Killer 1 (BAK1) Antibody |
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20-abx175548 | Abbexa |
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![]() Bcl2 Antagonist/Killer 1 (BAK1) Antibody |
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20-abx211066 | Abbexa |
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![]() Bcl2 Antagonist/Killer 1 (BAK1) Antibody |
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20-abx211310 | Abbexa |
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![]() Bcl2 Antagonist/Killer 1 (BAK1) Antibody |
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abx330690-100ul | Abbexa | 100 ul | EUR 425 |
![]() Bcl2 Antagonist/Killer 1 (BAK1) Antibody |
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20-abx326092 | Abbexa |
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![]() Custom production of antibodies in 5 Rats using customer supplied antigen (std 63 days protocol) |
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RAT-5 | Alpha Diagnostics | 1 | EUR 1138 |
![]() Bovine B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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DLR-Bcl2-b-48T | DL Develop | 48T | EUR 493 |
Description: A sandwich quantitative ELISA assay kit for detection of Bovine B-Cell Leukemia/Lymphoma 2 (Bcl2) in samples from serum, plasma, tissue homogenates or other biological fluids. |
![]() Bovine B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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DLR-Bcl2-b-96T | DL Develop | 96T | EUR 641 |
Description: A sandwich quantitative ELISA assay kit for detection of Bovine B-Cell Leukemia/Lymphoma 2 (Bcl2) in samples from serum, plasma, tissue homogenates or other biological fluids. |
![]() Human B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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DLR-Bcl2-Hu-48T | DL Develop | 48T | EUR 425 |
Description: A sandwich quantitative ELISA assay kit for detection of Human B-Cell Leukemia/Lymphoma 2 (Bcl2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
![]() Human B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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DLR-Bcl2-Hu-96T | DL Develop | 96T | EUR 548 |
Description: A sandwich quantitative ELISA assay kit for detection of Human B-Cell Leukemia/Lymphoma 2 (Bcl2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
![]() Mouse B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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DLR-Bcl2-Mu-48T | DL Develop | 48T | EUR 435 |
Description: A sandwich quantitative ELISA assay kit for detection of Mouse B-Cell Leukemia/Lymphoma 2 (Bcl2) in samples from serum, plasma, tissue homogenates or other biological fluids. |
![]() Mouse B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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DLR-Bcl2-Mu-96T | DL Develop | 96T | EUR 561 |
Description: A sandwich quantitative ELISA assay kit for detection of Mouse B-Cell Leukemia/Lymphoma 2 (Bcl2) in samples from serum, plasma, tissue homogenates or other biological fluids. |
![]() Bovine B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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RD-Bcl2-b-48Tests | Reddot Biotech | 48 Tests | EUR 494 |
![]() Bovine B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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RD-Bcl2-b-96Tests | Reddot Biotech | 96 Tests | EUR 684 |
![]() Human B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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RD-Bcl2-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 418 |
![]() Human B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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RD-Bcl2-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 575 |
![]() Mouse B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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RD-Bcl2-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 429 |
![]() Mouse B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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RD-Bcl2-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 591 |
![]() Bovine B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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RDR-Bcl2-b-48Tests | Reddot Biotech | 48 Tests | EUR 516 |
![]() Bovine B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit |
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RDR-Bcl2-b-96Tests | Reddot Biotech | 96 Tests | EUR 716 |